Abstract：
Three new nor-eremophilane sesquiterpenoids, namely nor-eremophilanol A-C (1-3), along with two known eremophilanes (4-5), were isolated from the culture of the fungus Penicillium sp. L1 that was obtained from the surface of basalt fibre composite bars. The structures of the new compounds were elucidated by a combined analysis of the 1D, 2D NMR, and HRMS spectroscopic data, and the absolute configuration of 1 was determined by the modified Mosher\'s method. The biosynthetic pathway leading to the nor-eremophilanes were proposed with the oxidative cleavage of the double bond as a key step. Compound 1 displayed antibacterial activities against the tested pathogenic bacteria.
摘要：
三种新的nor-emophilane倍半萜，即嗜红醇A-C(1-3)，连同两种已知的嗜乙菌（4-5），从真菌青霉的培养物中分离出来。从玄武岩纤维复合棒材表面获得的L1。通过对1D的联合分析，阐明了新化合物的结构，2DNMR,和HRMS光谱数据，1的绝对构型由改进的Mosher方法确定。提出了以双键的氧化裂解为关键步骤的生物合成途径。化合物1对所测试的病原菌表现出抗菌活性。
