Abstract：
OBJECTIVE: Hyperemesis gravidarum has the potential to affect the long-term health of offspring. We examined whether maternal hyperemesis gravidarum was associated with the risk of hospitalization for childhood morbidity.
METHODS: We conducted a longitudinal cohort study of 1,189,000 children born in Quebec, Canada, between April 2006 and March 2021. The main exposure measure was maternal hyperemesis gravidarum requiring hospitalization in the first or second trimester. The outcome was any pediatric admission between birth and 16 years of age, with follow-up ending in March 2022. We used Cox regression models adjusted for maternal and socioeconomic factors to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between maternal hyperemesis gravidarum and childhood hospitalization.
RESULTS: Among 1,189,000 children, 6904 (0.6%) were exposed to maternal hyperemesis gravidarum. Hospitalization rates at age 16 years were higher for children exposed to hyperemesis gravidarum than unexposed children (47.6 vs 43.9 per 100 children). Relative to no exposure, hyperemesis gravidarum was associated with a 1.21 times greater risk of any hospitalization before 16 years (95% CI 1.17-1.26). Hyperemesis gravidarum was associated with hospitalization for neurologic (HR 1.50, 95% CI 1.32-1.71), developmental (HR 1.51, 95% CI 1.29-1.76), digestive (HR 1.40, 95% CI 1.30-1.52), and allergic disorders (HR 1.39, 95% CI 1.24-1.56). When contrasted with preeclampsia, hyperemesis gravidarum was a stronger risk factor for these outcomes.
CONCLUSIONS: Maternal hyperemesis gravidarum is associated with an increased risk of childhood hospitalization, especially for neurologic, developmental, digestive, and atopic disorders.
BACKGROUND: • Hyperemesis gravidarum is associated with neurodevelopmental disorders in offspring. • However, the effect of hyperemesis gravidarum on other childhood morbidity is unclear.
BACKGROUND: • In this longitudinal cohort study of 1.2 million children, maternal hyperemesis gravidarum was associated with a greater risk of hospitalization before age 16 years. • Exposure to hyperemesis gravidarum was associated with developmental, neurologic, atopic, and digestive morbidity in childhood.
METHODS: We conducted a longitudinal cohort study of 1,189,000 children born in Quebec, Canada, between April 2006 and March 2021. The main exposure measure was maternal hyperemesis gravidarum requiring hospitalization in the first or second trimester. The outcome was any pediatric admission between birth and 16 years of age, with follow-up ending in March 2022. We used Cox regression models adjusted for maternal and socioeconomic factors to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between maternal hyperemesis gravidarum and childhood hospitalization.
RESULTS: Among 1,189,000 children, 6904 (0.6%) were exposed to maternal hyperemesis gravidarum. Hospitalization rates at age 16 years were higher for children exposed to hyperemesis gravidarum than unexposed children (47.6 vs 43.9 per 100 children). Relative to no exposure, hyperemesis gravidarum was associated with a 1.21 times greater risk of any hospitalization before 16 years (95% CI 1.17-1.26). Hyperemesis gravidarum was associated with hospitalization for neurologic (HR 1.50, 95% CI 1.32-1.71), developmental (HR 1.51, 95% CI 1.29-1.76), digestive (HR 1.40, 95% CI 1.30-1.52), and allergic disorders (HR 1.39, 95% CI 1.24-1.56). When contrasted with preeclampsia, hyperemesis gravidarum was a stronger risk factor for these outcomes.
CONCLUSIONS: Maternal hyperemesis gravidarum is associated with an increased risk of childhood hospitalization, especially for neurologic, developmental, digestive, and atopic disorders.
BACKGROUND: • Hyperemesis gravidarum is associated with neurodevelopmental disorders in offspring. • However, the effect of hyperemesis gravidarum on other childhood morbidity is unclear.
BACKGROUND: • In this longitudinal cohort study of 1.2 million children, maternal hyperemesis gravidarum was associated with a greater risk of hospitalization before age 16 years. • Exposure to hyperemesis gravidarum was associated with developmental, neurologic, atopic, and digestive morbidity in childhood.
摘要：
目的：妊娠剧吐有可能影响后代的长期健康。我们检查了孕妇妊娠剧吐是否与儿童发病率住院风险相关。
方法：我们对魁北克出生的1,189,000名儿童进行了纵向队列研究。加拿大,2006年4月至2021年3月。主要的暴露措施是孕妇妊娠剧吐，需要在妊娠早期或中期住院。结果是出生至16岁之间的任何儿科入院，后续行动将于2022年3月结束。我们使用Cox回归模型对母体和社会经济因素进行校正，以估计母体妊娠剧吐与儿童住院之间的关联的风险比（HR）和95％置信区间（CI）。
结果：在1,189,000名儿童中，6904（0.6％）暴露于母体妊娠剧吐。暴露于妊娠剧吐的儿童在16岁时的住院率高于未暴露的儿童（每100名儿童中有47.6对43.9）。相对于没有暴露，妊娠剧吐与16年前住院风险增加1.21倍相关(95%CI1.17~1.26).妊娠剧吐与神经内科住院相关(HR1.50,95%CI1.32-1.71),发育（HR1.51，95%CI1.29-1.76），消化性（HR1.40，95%CI1.30-1.52），和过敏性疾病（HR1.39，95%CI1.24-1.56）。当与先兆子痫对比时，妊娠剧吐是这些结局的更强危险因素.
结论：孕妇妊娠剧吐与儿童住院风险增加有关，尤其是对于神经系统，发展,消化性,和特应性疾病。
背景：•妊娠剧吐与后代的神经发育障碍有关。•However,妊娠剧吐对其他儿童发病率的影响尚不清楚.
背景：•在这项针对120万儿童的纵向队列研究中，孕妇妊娠剧吐与16岁前住院风险增加相关.•妊娠剧吐暴露与发育有关，神经学，特应性,和儿童时期的消化系统发病率。
方法：我们对魁北克出生的1,189,000名儿童进行了纵向队列研究。加拿大,2006年4月至2021年3月。主要的暴露措施是孕妇妊娠剧吐，需要在妊娠早期或中期住院。结果是出生至16岁之间的任何儿科入院，后续行动将于2022年3月结束。我们使用Cox回归模型对母体和社会经济因素进行校正，以估计母体妊娠剧吐与儿童住院之间的关联的风险比（HR）和95％置信区间（CI）。
结果：在1,189,000名儿童中，6904（0.6％）暴露于母体妊娠剧吐。暴露于妊娠剧吐的儿童在16岁时的住院率高于未暴露的儿童（每100名儿童中有47.6对43.9）。相对于没有暴露，妊娠剧吐与16年前住院风险增加1.21倍相关(95%CI1.17~1.26).妊娠剧吐与神经内科住院相关(HR1.50,95%CI1.32-1.71),发育（HR1.51，95%CI1.29-1.76），消化性（HR1.40，95%CI1.30-1.52），和过敏性疾病（HR1.39，95%CI1.24-1.56）。当与先兆子痫对比时，妊娠剧吐是这些结局的更强危险因素.
结论：孕妇妊娠剧吐与儿童住院风险增加有关，尤其是对于神经系统，发展,消化性,和特应性疾病。
背景：•妊娠剧吐与后代的神经发育障碍有关。•However,妊娠剧吐对其他儿童发病率的影响尚不清楚.
背景：•在这项针对120万儿童的纵向队列研究中，孕妇妊娠剧吐与16岁前住院风险增加相关.•妊娠剧吐暴露与发育有关，神经学，特应性,和儿童时期的消化系统发病率。
