Abstract：
The electrical impulses that coordinate the sequential, rhythmic contractions of the atria and ventricles are initiated and tightly regulated by the specialized tissues of the cardiac conduction system. In the mature heart, these impulses are generated by the pacemaker cardiomyocytes of the sinoatrial node, propagated through the atria to the atrioventricular node where they are delayed and then rapidly propagated to the atrioventricular bundle, right and left bundle branches, and finally, the peripheral ventricular conduction system. Each of these specialized components arise by complex patterning events during embryonic development. This chapter addresses the origins and transcriptional networks and signaling pathways that drive the development and maintain the function of the cardiac conduction system.
摘要：
协调顺序的电脉冲，心房和心室的节律性收缩由心脏传导系统的专门组织启动并严格调节。在成熟的心中，这些冲动是由窦房结的起搏器心肌细胞产生的，通过心房传播到房室结，在那里它们被延迟，然后迅速传播到房室束，右束和左束分支，最后，周围心室传导系统。这些特殊成分中的每一个都是由胚胎发育过程中复杂的模式事件产生的。本章介绍了推动心脏传导系统发展和维持功能的起源和转录网络和信号通路。
