Abstract：
OBJECTIVE: To elucidate the prognostic implications of mucosal and deep margin distances in oral tongue squamous cell carcinoma (OTSCC), and to assess a different margin cut-off value in T1-T2 versus T3-T4 tumors.
METHODS: This single-center retrospective study included 223 patients who received surgery for a primary OTSCC between January 2017 and December 2021.
RESULTS: Multivariable analysis showed that deep margin distance ≥3 mm in T1-T2 tumors and ≥5 mm in T3-T4 tumors was significantly associated with better RFS and OS. Mucosal and deep margin distances were globally clinically useful for 2-year RFS prediction of T1-T2 tumors, for which deep margins seemed to have more clinical utility than mucosal margins. The influence of margin distances on 2-year RFS seemed greater for T1-T2 tumors than T3-T4 tumors.
CONCLUSIONS: Mucosal and deep margin distances were associated with OS and RFS in OTSCC. Shorter deep margin distances may be aimed for in T1-T2 versus T3-T4 tumors.
METHODS: This single-center retrospective study included 223 patients who received surgery for a primary OTSCC between January 2017 and December 2021.
RESULTS: Multivariable analysis showed that deep margin distance ≥3 mm in T1-T2 tumors and ≥5 mm in T3-T4 tumors was significantly associated with better RFS and OS. Mucosal and deep margin distances were globally clinically useful for 2-year RFS prediction of T1-T2 tumors, for which deep margins seemed to have more clinical utility than mucosal margins. The influence of margin distances on 2-year RFS seemed greater for T1-T2 tumors than T3-T4 tumors.
CONCLUSIONS: Mucosal and deep margin distances were associated with OS and RFS in OTSCC. Shorter deep margin distances may be aimed for in T1-T2 versus T3-T4 tumors.
摘要：
目的：为了阐明口腔舌鳞状细胞癌（OTSCC）的粘膜和深缘距离的预后意义，并评估T1-T2与T3-T4肿瘤的不同切缘值。
方法：这项单中心回顾性研究纳入了223例患者，这些患者在2017年1月至2021年12月期间接受了原发性OTSCC手术。
结果：多变量分析表明，T1-T2肿瘤的深缘距离≥3mm和T3-T4肿瘤的深缘距离≥5mm与更好的RFS和OS显著相关。粘膜和深缘距离对T1-T2肿瘤的2年RFS预测在全球范围内是有用的，对于深边缘似乎比粘膜边缘具有更多的临床应用。T1-T2肿瘤的边缘距离对2年RFS的影响似乎大于T3-T4肿瘤。
结论：OTSCC中粘膜和深缘距离与OS和RFS相关。较短的深缘距离可能针对T1-T2与T3-T4肿瘤。
方法：这项单中心回顾性研究纳入了223例患者，这些患者在2017年1月至2021年12月期间接受了原发性OTSCC手术。
结果：多变量分析表明，T1-T2肿瘤的深缘距离≥3mm和T3-T4肿瘤的深缘距离≥5mm与更好的RFS和OS显著相关。粘膜和深缘距离对T1-T2肿瘤的2年RFS预测在全球范围内是有用的，对于深边缘似乎比粘膜边缘具有更多的临床应用。T1-T2肿瘤的边缘距离对2年RFS的影响似乎大于T3-T4肿瘤。
结论：OTSCC中粘膜和深缘距离与OS和RFS相关。较短的深缘距离可能针对T1-T2与T3-T4肿瘤。
