PDF(Pubmed)
Abstract：
UNASSIGNED: Dengue is a vector-borne viral disease impacting millions across the globe. Nevertheless, akin to many other diseases, reports indicated a decline in dengue incidence and seroprevalence during the COVID-19 pandemic (2020-22). This presumably could be attributed to reduced treatment-seeking rates, under-reporting, misdiagnosis, disrupted health services and reduced exposure to vectors due to lockdowns. Scientific evidence on dengue virus (DENV) disease during the COVID-19 pandemic is limited globally.
UNASSIGNED: A cross-sectional, randomized cluster sampling community-based survey was carried out to assess anti-dengue IgM and IgG and SARS-CoV-2 IgG seroprevalence across all 38 districts of Tamil Nadu, India. The prevalence of DENV in the Aedes mosquito pools during 2021 was analyzed and compared with previous and following years of vector surveillance for DENV by real-time PCR.
UNASSIGNED: Results implicate that both DENV-IgM and IgG seroprevalence and mosquito viral positivity were reduced across all the districts. A total of 13464 mosquito pools and 5577 human serum samples from 186 clusters were collected. Of these, 3·76% of mosquito pools were positive for DENV. In the human sera, 4·12% were positive for DENV IgM and 6·4% were positive for DENV IgG. The anti-SARS-CoV-2 antibody titres correlated with dengue seropositivity with a significant association whereas vaccination status significantly correlated with dengue IgM levels.
UNASSIGNED: Continuous monitoring of DENV seroprevalence, especially with the evolving variants of the SARS-CoV-2 virus and surge in COVID-19 cases will shed light on the transmission and therapeutic attributes of dengue infection.
UNASSIGNED: A cross-sectional, randomized cluster sampling community-based survey was carried out to assess anti-dengue IgM and IgG and SARS-CoV-2 IgG seroprevalence across all 38 districts of Tamil Nadu, India. The prevalence of DENV in the Aedes mosquito pools during 2021 was analyzed and compared with previous and following years of vector surveillance for DENV by real-time PCR.
UNASSIGNED: Results implicate that both DENV-IgM and IgG seroprevalence and mosquito viral positivity were reduced across all the districts. A total of 13464 mosquito pools and 5577 human serum samples from 186 clusters were collected. Of these, 3·76% of mosquito pools were positive for DENV. In the human sera, 4·12% were positive for DENV IgM and 6·4% were positive for DENV IgG. The anti-SARS-CoV-2 antibody titres correlated with dengue seropositivity with a significant association whereas vaccination status significantly correlated with dengue IgM levels.
UNASSIGNED: Continuous monitoring of DENV seroprevalence, especially with the evolving variants of the SARS-CoV-2 virus and surge in COVID-19 cases will shed light on the transmission and therapeutic attributes of dengue infection.
摘要：
登革热是一种媒介传播的病毒性疾病，影响全球数百万人。然而，类似于许多其他疾病，报告显示，在COVID-19大流行期间（2020-22），登革热发病率和血清阳性率下降。这可能归因于寻求治疗的比率降低，少报,误诊,由于封锁，中断了卫生服务，减少了对病媒的接触。关于COVID-19大流行期间登革热病毒(DENV)疾病的科学证据在全球范围内是有限的。
■横截面，进行了随机整群抽样的社区调查，以评估泰米尔纳德邦所有38个地区的抗登革热IgM和IgG和SARS-CoV-2IgG血清阳性率，印度。对2021年伊蚊蚊池中DENV的患病率进行了分析，并通过实时PCR将其与之前和之后几年的DENV载体监测进行了比较。
■结果表明，所有地区的DENV-IgM和IgG血清阳性率和蚊子病毒阳性率均降低。共收集了来自186个集群的13464个蚊子池和5577个人血清样品。其中,3.76%的蚊子池对DENV呈阳性。在人类血清中，4·12%的DENVIgM阳性，6·4%的DENVIgG阳性。抗SARS-CoV-2抗体滴度与登革热血清阳性呈显着相关性，而疫苗接种状态与登革热IgM水平显着相关。
■持续监测DENV血清阳性率，特别是随着SARS-CoV-2病毒的变异和COVID-19病例的激增，将揭示登革热感染的传播和治疗属性。
■横截面，进行了随机整群抽样的社区调查，以评估泰米尔纳德邦所有38个地区的抗登革热IgM和IgG和SARS-CoV-2IgG血清阳性率，印度。对2021年伊蚊蚊池中DENV的患病率进行了分析，并通过实时PCR将其与之前和之后几年的DENV载体监测进行了比较。
■结果表明，所有地区的DENV-IgM和IgG血清阳性率和蚊子病毒阳性率均降低。共收集了来自186个集群的13464个蚊子池和5577个人血清样品。其中,3.76%的蚊子池对DENV呈阳性。在人类血清中，4·12%的DENVIgM阳性，6·4%的DENVIgG阳性。抗SARS-CoV-2抗体滴度与登革热血清阳性呈显着相关性，而疫苗接种状态与登革热IgM水平显着相关。
■持续监测DENV血清阳性率，特别是随着SARS-CoV-2病毒的变异和COVID-19病例的激增，将揭示登革热感染的传播和治疗属性。
