PDF(Pubmed)
Abstract：
UNASSIGNED: Iodine serves as a crucial precursor for the synthesis of thyroid hormones and plays an import role in both pregnant women and their offspring. The relationships between iodine nutritional status and maternal thyroid function and neonatal outcomes remain inconclusive in areas with adequate iodine nutrition. This study aims to investigate their correlations.
UNASSIGNED: Blood, morning urine and 24-hour urine were collected from the pregnant women to measure thyroid functions, serum iodine concentration (SIC), morning urine iodine concentration (UIC) and 24-hour urine iodine excretion (24-hour UIE). Indicators of their offspring\'s neonatal indexes were recorded.
UNASSIGNED: A total of 559 pregnant women were enrolled in this study. The iodine indicators including Tg, 24-hour UIE and morning UIC were significantly different among the euthyroid pregnant women and those with different thyroid disorders. The levels of FT3, FT4, and SIC exhibited a gradual decline and the concentration of TSH exhibited a gradual increase trend throughout the progression of pregnancy in euthyroid pregnant women. There were no significant differences in neonatal outcomes and neonatal TSH values among euthyroid pregnant women and thyroid disorders pregnant women. SIC had a significant impact on maternal FT4 levels throughout all three trimesters, with varying degrees of importance observed in each trimester. TSH level emerged as the primary determinant of FT4 during the first trimester, while SIC exerted a predominant influence on FT4 levels in the second and third trimesters. The prevalence of thyroid disorders in pregnant women was the lowest when the SIC of pregnant women was probable in the range of 60~70 μg/L, 24-hours UIE was in the range of 250~450 μg, and Tg was in the range of 9~21 μg/L. Maternal TSH exhibited a notable influence on neonatal TSH levels, particularly at the 50th and 75th quantiles. Among the iodine nutritional indicators, SIC and morning UIC demonstrated higher AUC values for abnormal FT4 and TSH, respectively.
UNASSIGNED: The iodine nutrition status of pregnant women exerts an impact on their thyroid function and prevalence of thyroid disorders, and neonatal TSH was affected by maternal TSH. SIC may be a better indicator for iodine nutritional assessment than other indexes.
UNASSIGNED: Blood, morning urine and 24-hour urine were collected from the pregnant women to measure thyroid functions, serum iodine concentration (SIC), morning urine iodine concentration (UIC) and 24-hour urine iodine excretion (24-hour UIE). Indicators of their offspring\'s neonatal indexes were recorded.
UNASSIGNED: A total of 559 pregnant women were enrolled in this study. The iodine indicators including Tg, 24-hour UIE and morning UIC were significantly different among the euthyroid pregnant women and those with different thyroid disorders. The levels of FT3, FT4, and SIC exhibited a gradual decline and the concentration of TSH exhibited a gradual increase trend throughout the progression of pregnancy in euthyroid pregnant women. There were no significant differences in neonatal outcomes and neonatal TSH values among euthyroid pregnant women and thyroid disorders pregnant women. SIC had a significant impact on maternal FT4 levels throughout all three trimesters, with varying degrees of importance observed in each trimester. TSH level emerged as the primary determinant of FT4 during the first trimester, while SIC exerted a predominant influence on FT4 levels in the second and third trimesters. The prevalence of thyroid disorders in pregnant women was the lowest when the SIC of pregnant women was probable in the range of 60~70 μg/L, 24-hours UIE was in the range of 250~450 μg, and Tg was in the range of 9~21 μg/L. Maternal TSH exhibited a notable influence on neonatal TSH levels, particularly at the 50th and 75th quantiles. Among the iodine nutritional indicators, SIC and morning UIC demonstrated higher AUC values for abnormal FT4 and TSH, respectively.
UNASSIGNED: The iodine nutrition status of pregnant women exerts an impact on their thyroid function and prevalence of thyroid disorders, and neonatal TSH was affected by maternal TSH. SIC may be a better indicator for iodine nutritional assessment than other indexes.
摘要：
■碘是甲状腺激素合成的关键前体，对孕妇及其后代都起着重要作用。在碘营养充足的地区，碘营养状况与产妇甲状腺功能和新生儿结局之间的关系仍然没有定论。本研究旨在探讨它们的相关性。
■血液，收集孕妇的早晨尿液和24小时尿液以测量甲状腺功能，血清碘浓度（SIC），晨尿碘浓度（UIC）和24小时尿碘排泄（24小时UIE）。记录其后代的新生儿指标。
■本研究共纳入559名孕妇。碘指标包括Tg，24小时UIE和早晨UIC在甲状腺功能正常的孕妇和甲状腺疾病不同的孕妇之间存在显着差异。在甲状腺功能正常的孕妇中，FT3，FT4和SIC的水平在整个妊娠过程中呈逐渐下降的趋势，TSH的浓度呈逐渐增加的趋势。甲状腺功能正常孕妇和甲状腺疾病孕妇的新生儿结局和新生儿TSH值没有显着差异。在所有三个孕期，SIC对产妇FT4水平都有显著影响，在每个三个月中观察到不同程度的重要性。TSH水平在孕早期成为FT4的主要决定因素，而SIC在第二和第三三个月对FT4水平产生了主要影响。当孕妇的SIC可能在60〜70μg/L范围内时，孕妇甲状腺疾病的患病率最低。24小时UIE在250~450μg范围内，Tg在9~21μg/L范围内产妇TSH对新生儿TSH水平有显著影响，特别是在第50和第75分位数。在碘营养指标中，SIC和早晨UIC显示异常FT4和TSH的AUC值较高，分别。
■孕妇的碘营养状况对其甲状腺功能和甲状腺疾病的患病率有影响，新生儿TSH受母体TSH影响。SIC可能是比其他指标更好的碘营养评估指标。
■血液，收集孕妇的早晨尿液和24小时尿液以测量甲状腺功能，血清碘浓度（SIC），晨尿碘浓度（UIC）和24小时尿碘排泄（24小时UIE）。记录其后代的新生儿指标。
■本研究共纳入559名孕妇。碘指标包括Tg，24小时UIE和早晨UIC在甲状腺功能正常的孕妇和甲状腺疾病不同的孕妇之间存在显着差异。在甲状腺功能正常的孕妇中，FT3，FT4和SIC的水平在整个妊娠过程中呈逐渐下降的趋势，TSH的浓度呈逐渐增加的趋势。甲状腺功能正常孕妇和甲状腺疾病孕妇的新生儿结局和新生儿TSH值没有显着差异。在所有三个孕期，SIC对产妇FT4水平都有显著影响，在每个三个月中观察到不同程度的重要性。TSH水平在孕早期成为FT4的主要决定因素，而SIC在第二和第三三个月对FT4水平产生了主要影响。当孕妇的SIC可能在60〜70μg/L范围内时，孕妇甲状腺疾病的患病率最低。24小时UIE在250~450μg范围内，Tg在9~21μg/L范围内产妇TSH对新生儿TSH水平有显著影响，特别是在第50和第75分位数。在碘营养指标中，SIC和早晨UIC显示异常FT4和TSH的AUC值较高，分别。
■孕妇的碘营养状况对其甲状腺功能和甲状腺疾病的患病率有影响，新生儿TSH受母体TSH影响。SIC可能是比其他指标更好的碘营养评估指标。
