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Abstract：
OBJECTIVE: To investigate the clinical significance of plasma p-amyloid 1-40 (Aβ1-40) in patients with Alzheimer\'s disease (AD).
METHODS: In this retrospective study, the clinical data of 305 patients, with or without Alzheimer\'s disease (AD), who were treated at the Affiliated Hospital of Youjiang Medical University for Nationalities and the People\'s Hospital of Baise between January 2018 and December 2021 were analyzed. Patients were divided into two groups: an AD group (n=147) and a non-AD group (without AD, n=158 cases). Blood test indices, including serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine (CRE), high-sensitivity C-reactive protein (hsCRP), and plasma β-amyloid 1-40 were collected and compared between the two groups.
RESULTS: The plasma β-amyloid 1-40 in the AD group was (3.71±3.45) mol/L, which was significantly higher than (2.8±1.35) mmol/L in the non-AD group (P<0.05). Similarly, hsCRP expression was significantly higher in the AD group than that in the non-AD group (P<0.05). There were no significant differences in AST, ALT, UA, T-tau, NFL or Cr levels between the two groups (all P>0.05). Moreover, univariate regression analysis showed that plasma β-amyloid 1-40 and hsCRP were significantly correlated with AD. Multiple regression analysis demonstrated that plasma p-amyloid 1-40 (P<0.0001) and hsCRP (P=0.002) were independent predictors of AD.
CONCLUSIONS: Plasma p-amyloid 1-40 and hsCRP are closely related to AD, and may serve as important clinical predictors of AD.
METHODS: In this retrospective study, the clinical data of 305 patients, with or without Alzheimer\'s disease (AD), who were treated at the Affiliated Hospital of Youjiang Medical University for Nationalities and the People\'s Hospital of Baise between January 2018 and December 2021 were analyzed. Patients were divided into two groups: an AD group (n=147) and a non-AD group (without AD, n=158 cases). Blood test indices, including serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine (CRE), high-sensitivity C-reactive protein (hsCRP), and plasma β-amyloid 1-40 were collected and compared between the two groups.
RESULTS: The plasma β-amyloid 1-40 in the AD group was (3.71±3.45) mol/L, which was significantly higher than (2.8±1.35) mmol/L in the non-AD group (P<0.05). Similarly, hsCRP expression was significantly higher in the AD group than that in the non-AD group (P<0.05). There were no significant differences in AST, ALT, UA, T-tau, NFL or Cr levels between the two groups (all P>0.05). Moreover, univariate regression analysis showed that plasma β-amyloid 1-40 and hsCRP were significantly correlated with AD. Multiple regression analysis demonstrated that plasma p-amyloid 1-40 (P<0.0001) and hsCRP (P=0.002) were independent predictors of AD.
CONCLUSIONS: Plasma p-amyloid 1-40 and hsCRP are closely related to AD, and may serve as important clinical predictors of AD.
摘要：
目的：探讨阿尔茨海默病(AD)患者血浆β-淀粉样蛋白1-40(Aβ1-40)的临床意义。
方法：在这项回顾性研究中，305例患者的临床资料,有或没有阿尔茨海默病（AD），对2018年1月至2021年12月在右江民族医学院附属医院和百色市人民医院治疗的患者进行分析。患者分为两组：AD组（n=147）和非AD组（无AD，n=158例）。验血指标,包括血清天冬氨酸转氨酶（AST），丙氨酸氨基转移酶（ALT），肌酐（CRE），高敏C反应蛋白（hsCRP），收集并比较两组的血浆β-淀粉样蛋白1-40。
结果:AD组血浆β-淀粉样蛋白1-40为(3.71±3.45)mol/L,显著高于非AD组的(2.8±1.35)mmol/L(P<0.05)。同样，AD组hsCRP表达明显高于非AD组(P<0.05)。AST没有显著差异，ALT,UA,T-tau,两组间NFL或Cr水平比较(均P>0.05)。此外，单因素回归分析显示，血浆β-淀粉样蛋白1-40和hsCRP与AD显著相关。多元回归分析显示血浆β-淀粉样蛋白1-40(P<0.0001)和hsCRP(P=0.002)是AD的独立预测因子。
结论：血浆β-淀粉样蛋白1-40和hsCRP与AD密切相关。并可能作为AD的重要临床预测因子。
方法：在这项回顾性研究中，305例患者的临床资料,有或没有阿尔茨海默病（AD），对2018年1月至2021年12月在右江民族医学院附属医院和百色市人民医院治疗的患者进行分析。患者分为两组：AD组（n=147）和非AD组（无AD，n=158例）。验血指标,包括血清天冬氨酸转氨酶（AST），丙氨酸氨基转移酶（ALT），肌酐（CRE），高敏C反应蛋白（hsCRP），收集并比较两组的血浆β-淀粉样蛋白1-40。
结果:AD组血浆β-淀粉样蛋白1-40为(3.71±3.45)mol/L,显著高于非AD组的(2.8±1.35)mmol/L(P<0.05)。同样，AD组hsCRP表达明显高于非AD组(P<0.05)。AST没有显著差异，ALT,UA,T-tau,两组间NFL或Cr水平比较(均P>0.05)。此外，单因素回归分析显示，血浆β-淀粉样蛋白1-40和hsCRP与AD显著相关。多元回归分析显示血浆β-淀粉样蛋白1-40(P<0.0001)和hsCRP(P=0.002)是AD的独立预测因子。
结论：血浆β-淀粉样蛋白1-40和hsCRP与AD密切相关。并可能作为AD的重要临床预测因子。
