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Abstract：
Immune-mediated necrotizing myopathy (IMNM) represents a rare category of inflammatory myopathies characterized by more severe and rapid progression of symmetrical proximal muscle weakness. It is also marked by notably elevated serum muscle enzyme levels and distinct histological features, setting it apart from other types of myositis. Moreover, acute chronic lung respiratory dysfunction is a major comorbidity of great concern. We herein present two cases of IMNM associated with anti-signal recognition particle antibodies complicated by acute respiratory distress syndrome.
摘要：
免疫介导的坏死性肌病（IMNM）是一种罕见的炎症性肌病，其特征是对称的近端肌无力的严重和快速进展。它还具有明显升高的血清肌肉酶水平和明显的组织学特征，将其与其他类型的肌炎区分开来。此外，急性慢性肺呼吸功能障碍是备受关注的主要合并症。我们在此介绍了两例与抗信号识别颗粒抗体相关的IMNM并发急性呼吸窘迫综合征。
