PDF(Pubmed)
Abstract：
Dextrose cross-linked glutaraldehyde hydrogels are effective and promising drug delivery candidates. The addition of chitosan with dextrose resulted in the polymerization of material which resulted in the production of a gel-like structure that was highly viscous and had gelling properties. A swelling and absorption assay was conducted on the hydrogel. The dextrose cross-linked hydrogel has a higher absorption potential for distilled water followed by PBS and the least absorption was observed in the ethanol. Dextrose cross-linked hydrogel favors solubility in distilled water as compared to other solvents. The amoxicillin release by the dextrose cross-linked hydrogel was then tested. The result from drug release demonstrates that the dextrose cross-linked hydrogel released more than 55% of the amoxicillin in 2 hours and the remaining portion of the drug remaining. Therefore, it has a slow drug-release property, and it can be used for further wound-healing studies.
摘要：
葡萄糖交联的戊二醛水凝胶是有效且有前景的药物递送候选物。壳聚糖与右旋糖的添加导致材料的聚合,这导致产生高度粘稠且具有胶凝性质的凝胶状结构。对水凝胶进行溶胀和吸收测定。右旋糖交联的水凝胶对蒸馏水和PBS具有较高的吸收潜力,并且在乙醇中观察到最小的吸收。与其它溶剂相比,右旋糖交联的水凝胶有利于在蒸馏水中的溶解性。然后测试右旋糖交联水凝胶的阿莫西林释放。药物释放的结果表明,右旋糖交联的水凝胶在2小时内释放了超过55%的阿莫西林和剩余部分的药物。因此,它具有缓慢的药物释放特性，它可以用于进一步的伤口愈合研究。
