PDF(Pubmed)
Abstract：
The investigation of biomarkers is constantly evolving. New molecules and molecular assemblies, such as soluble and particulate complexes, emerged as biomarkers from basic research and investigation of different proteomes, genomes, and glycomes. Extracellular vesicles (EVs), and glycans, complex carbohydrates are ubiquitous in nature. The composition and structure of both reflect physiological state of paternal cells and are strikingly changed in diseases. The EV-associated glycans, alone or in combination with soluble glycans in related biological fluids, used as analytes, aim to capture full complex biomarker picture, enabling its use in different clinical settings. Bringing together EVs and glycans can help to extract meaningful data from their extreme and distinct heterogeneities for use in the real-time diagnostics. The glycans on the surface of EVs could mark their subpopulations and establish the glycosignature, the solubilisation signature and molecular patterns. They all contribute to a new way of looking at and looking for composite biomarkers.
摘要：
生物标志物的研究正在不断发展。新的分子和分子组装体，如可溶性和颗粒复合物，从基础研究和不同蛋白质组的研究中作为生物标志物出现，基因组，和糖。细胞外囊泡（EV），和聚糖，复杂的碳水化合物在自然界中无处不在。两者的组成和结构反映了父系细胞的生理状态，并在疾病中发生了显着变化。EV相关聚糖，单独或与相关生物流体中的可溶性聚糖组合，用作分析物，旨在捕捉完整复杂的生物标志物图片，使其能够在不同的临床环境中使用。将EV和聚糖结合在一起可以帮助从其极端和不同的异质性中提取有意义的数据，用于实时诊断。电动汽车表面的聚糖可以标记它们的亚群并建立糖标签，增溶特征和分子模式。它们都为寻找和寻找复合生物标志物的新途径做出了贡献。
