PDF(Pubmed)
Abstract：
Patients with epileptic encephalopathy with spike wave activation in sleep (EE-SWAS) often display drug-resistant epilepsy. The activation of epileptic activity during sleep is associated temporally with neurocognitive impairment and causes a spectrum of disorders within the epilepsy-aphasia syndrome. The prognosis is dependent on promptness of treatment and etiology. However, there is no clear consensus with regards to the optimal management for patients with EE-SWAS. We queried our Pediatric Epilepsy Outcome-Informatics Project (PEOIP) database for all patients treated with anakinra in our centre. We herein report a case of a female with EE-SWAS, who demonstrated remarkable neurocognitive improvement with anakinra. We suggest that a trial of anakinra may be an option for patients with EE-SWAS due to non-structural and possibly inflammatory etiology.
摘要：
具有睡眠中的尖峰波激活（EE-SWAS）的癫痫性脑病患者通常会表现出耐药性癫痫。睡眠期间癫痫活动的激活在时间上与神经认知障碍相关，并在癫痫-失语综合征中引起一系列疾病。预后取决于治疗的及时性和病因。然而,对于EE-SWAS患者的最佳管理,目前尚无明确共识.我们查询了我们的儿科癫痫预后信息学项目（PEOIP）数据库，以了解在我们中心接受anakinra治疗的所有患者。我们在此报告一例女性EE-SWAS，阿纳金拉表现出显著的神经认知改善。我们建议，由于非结构性和可能的炎症病因，对EE-SWAS患者进行anakinra试验可能是一种选择。
