Abstract：
This perspective underscores the rising challenge posed by emerging diseases against the backdrop of modern advancements in global public health understanding. It particularly highlights the emergence of the Oropouche virus (OROV) as a significant global threat, detailing its transmission dynamics, symptoms, and epidemiological impact, with a focus on its historical and current manifestations. It further delves into the molecular aspects of OROV, elucidating its unique characteristics, lack of structural similarity with other arboviruses, and the limited progress in medicinal chemistry research. Still, it highlights notable studies on potential antiviral agents and the challenges in drug development, emphasizing the need for innovative approaches such as structure-based drug design (SBDD) and drug repurposing. Finally, it concludes with a call to action, urging increased attention and research focus on OROV to prevent potential future pandemics fueled by viral mutations.
摘要：
这种观点强调了在全球公共卫生理解的现代进步的背景下，新兴疾病带来的日益严峻的挑战。它特别强调了Oropouche病毒（OROV）作为重大的全球威胁的出现，详细说明其传输动力学，症状,和流行病学影响，重点关注其历史和当前表现。它进一步深入研究了OROV的分子方面，阐明其独特的特征，与其他虫媒病毒缺乏结构相似性，以及药物化学研究的有限进展。尽管如此，它强调了有关潜在抗病毒药物的显着研究以及药物开发中的挑战，强调需要创新方法，如基于结构的药物设计（SBDD）和药物再利用。最后,它以行动呼吁结束，敦促增加对OROV的关注和研究，以防止病毒突变引发的潜在未来大流行。
