Abstract：
Mammalian innate-like T cells (ILTCs), including mucosal-associated invariant T (MAIT), natural killer T (NKT), and γδ T cells, are abundant tissue-resident lymphocytes that have recently emerged as orchestrators of hepatic inflammation, tissue repair, and immune homeostasis. This review explores the involvement of different ILTC subsets in liver diseases. We explore the mechanisms underlying the pro- and anti-inflammatory effector functions of ILTCs in a context-dependent manner. We highlight latest findings regarding the dynamic interplay between ILTC functional subsets and other immune and parenchymal cells which may inform candidate immunomodulatory strategies to achieve improved clinical outcomes in liver diseases. We present new insights into how distinct gene expression programs in hepatic ILTCs are induced, maintained, and reprogrammed in a context- and disease stage-dependent manner.
摘要：
哺乳动物先天样T细胞（ILTC），包括粘膜相关不变T(MAIT)，自然杀手T(NKT),和γδT细胞，是丰富的组织驻留淋巴细胞，最近已成为肝脏炎症的协调者，组织修复,和免疫稳态。本文就不同ILTC亚群在肝脏疾病中的作用作一综述。我们以上下文依赖的方式探索ILTC的促炎和抗炎效应子功能的潜在机制。我们强调有关ILTC功能亚群与其他免疫和实质细胞之间的动态相互作用的最新发现，这些发现可能为候选免疫调节策略提供信息，以改善肝病的临床结果。我们提出了关于肝脏ILTC中不同基因表达程序如何被诱导的新见解，维护,并以依赖上下文和疾病阶段的方式重新编程。
