METHODS: Burnout, childhood trauma, and job stress were assessed using rating scales in 992 general occupational individuals. Genetic polymorphisms including HTR2A rs6313, 5-HTT rs6354 and FAAH rs324420, were genotyped. Linear hierarchical regression analysis and PROCESS macro in SPSS were used to examine two- and three-way interactions.
RESULTS: There were significant interactions of job stress × HTR2A rs6313 and childhood abuse × FAAH rs324420 on reduced personal accomplishment. Moreover, we found significant three-way interactions of childhood abuse × FAAH rs324420 × HTR2A rs6313 on cynicism and reduced personal accomplishment, childhood abuse × FAAH rs324420 × 5-HTT rs6354 on emotional exhaustion, and childhood neglect × FAAH rs324420 × 5-HTT rs6354 on reduced personal accomplishment. These results suggest that the FAAH rs324420 A allele carriers, when with some specific genetic polymorphisms of 5-HT system, would show more positive associations between childhood trauma and burnout.
CONCLUSIONS: Genetic polymorphisms in the 5-HT and eCB systems may jointly moderate the impact of childhood trauma on burnout.
方法:倦怠,童年创伤,使用评定量表对992名一般职业个体进行了工作压力评估。对包括HTR2Ars6313,5-HTTrs6354和FAAHrs324420在内的遗传多态性进行了基因分型。使用SPSS中的线性分层回归分析和PROCESS宏检查双向和三向相互作用。
结果:工作压力×HTR2Ars6313和童年虐待×FAAHrs324420对个人成就感的降低存在显着相互作用。此外,我们发现儿童期虐待×FAAHrs324420×HTR2Ars6313对玩世不恭和个人成就感的显着三向互动,童年虐待×FAAHrs324420×5-HTTrs6354对情绪疲惫,和童年忽视×FAAHrs324420×5-HTTrs6354对个人成就感的降低。这些结果表明,FAAHrs324420A等位基因携带者,当5-HT系统具有某些特定的遗传多态性时,会显示童年创伤和倦怠之间更积极的联系。
结论:5-HT和eCB系统的遗传多态性可能共同减轻儿童创伤对职业倦怠的影响。