Abstract：
BACKGROUND: Interactions between the serotonin (5-HT) and endocannabinoid (eCB) systems have been reported in the psychopathology of stress-related symptoms, while their interplay in regulating the relationship between childhood trauma and burnout remains unclear. In this study, we investigated the interaction of childhood trauma with genetic polymorphisms in these two systems in predicting burnout.
METHODS: Burnout, childhood trauma, and job stress were assessed using rating scales in 992 general occupational individuals. Genetic polymorphisms including HTR2A rs6313, 5-HTT rs6354 and FAAH rs324420, were genotyped. Linear hierarchical regression analysis and PROCESS macro in SPSS were used to examine two- and three-way interactions.
RESULTS: There were significant interactions of job stress × HTR2A rs6313 and childhood abuse × FAAH rs324420 on reduced personal accomplishment. Moreover, we found significant three-way interactions of childhood abuse × FAAH rs324420 × HTR2A rs6313 on cynicism and reduced personal accomplishment, childhood abuse × FAAH rs324420 × 5-HTT rs6354 on emotional exhaustion, and childhood neglect × FAAH rs324420 × 5-HTT rs6354 on reduced personal accomplishment. These results suggest that the FAAH rs324420 A allele carriers, when with some specific genetic polymorphisms of 5-HT system, would show more positive associations between childhood trauma and burnout.
CONCLUSIONS: Genetic polymorphisms in the 5-HT and eCB systems may jointly moderate the impact of childhood trauma on burnout.
METHODS: Burnout, childhood trauma, and job stress were assessed using rating scales in 992 general occupational individuals. Genetic polymorphisms including HTR2A rs6313, 5-HTT rs6354 and FAAH rs324420, were genotyped. Linear hierarchical regression analysis and PROCESS macro in SPSS were used to examine two- and three-way interactions.
RESULTS: There were significant interactions of job stress × HTR2A rs6313 and childhood abuse × FAAH rs324420 on reduced personal accomplishment. Moreover, we found significant three-way interactions of childhood abuse × FAAH rs324420 × HTR2A rs6313 on cynicism and reduced personal accomplishment, childhood abuse × FAAH rs324420 × 5-HTT rs6354 on emotional exhaustion, and childhood neglect × FAAH rs324420 × 5-HTT rs6354 on reduced personal accomplishment. These results suggest that the FAAH rs324420 A allele carriers, when with some specific genetic polymorphisms of 5-HT system, would show more positive associations between childhood trauma and burnout.
CONCLUSIONS: Genetic polymorphisms in the 5-HT and eCB systems may jointly moderate the impact of childhood trauma on burnout.
摘要：
背景：在压力相关症状的精神病理学中，已经报道了5-羟色胺（5-HT）和内源性大麻素（eCB）系统之间的相互作用，虽然它们在调节童年创伤和倦怠之间的关系方面的相互作用仍不清楚。在这项研究中,我们研究了这两个系统中儿童创伤与遗传多态性在预测倦怠中的相互作用。
方法：倦怠，童年创伤,使用评定量表对992名一般职业个体进行了工作压力评估。对包括HTR2Ars6313，5-HTTrs6354和FAAHrs324420在内的遗传多态性进行了基因分型。使用SPSS中的线性分层回归分析和PROCESS宏检查双向和三向相互作用。
结果：工作压力×HTR2Ars6313和童年虐待×FAAHrs324420对个人成就感的降低存在显着相互作用。此外，我们发现儿童期虐待×FAAHrs324420×HTR2Ars6313对玩世不恭和个人成就感的显着三向互动，童年虐待×FAAHrs324420×5-HTTrs6354对情绪疲惫，和童年忽视×FAAHrs324420×5-HTTrs6354对个人成就感的降低。这些结果表明，FAAHrs324420A等位基因携带者，当5-HT系统具有某些特定的遗传多态性时，会显示童年创伤和倦怠之间更积极的联系。
结论：5-HT和eCB系统的遗传多态性可能共同减轻儿童创伤对职业倦怠的影响。
方法：倦怠，童年创伤,使用评定量表对992名一般职业个体进行了工作压力评估。对包括HTR2Ars6313，5-HTTrs6354和FAAHrs324420在内的遗传多态性进行了基因分型。使用SPSS中的线性分层回归分析和PROCESS宏检查双向和三向相互作用。
结果：工作压力×HTR2Ars6313和童年虐待×FAAHrs324420对个人成就感的降低存在显着相互作用。此外，我们发现儿童期虐待×FAAHrs324420×HTR2Ars6313对玩世不恭和个人成就感的显着三向互动，童年虐待×FAAHrs324420×5-HTTrs6354对情绪疲惫，和童年忽视×FAAHrs324420×5-HTTrs6354对个人成就感的降低。这些结果表明，FAAHrs324420A等位基因携带者，当5-HT系统具有某些特定的遗传多态性时，会显示童年创伤和倦怠之间更积极的联系。
结论：5-HT和eCB系统的遗传多态性可能共同减轻儿童创伤对职业倦怠的影响。
