Abstract：
BACKGROUND: Metabolic diseases contribute significantly to premature mortality worldwide, with increasing burdens observed among the working-age population (WAP). This study assessed global, regional, and national trends in metabolic disorders and associated mortality over three decades in WAP.
METHODS: Data from the Global Burden of Disease 2019 study were leveraged to assess global metabolism-associated mortality and six key metabolic risk factors in WAP from 1990-2019. An age-period-cohort model was employed to determine the overall percentage change in mortality.
RESULTS: The 2019 global metabolic risk-related mortality rate in WAP rose significantly by 50.73%, while the age-standardized mortality rate declined by 21.5%. India, China, Indonesia, the USA, and the Russian Federation were the top contributing countries to mortality in WAP, accounting for 51.01% of the total. High systolic blood pressure (HSBP), high body mass index (HBMI), and high fasting plasma glucose (HFPG) were the top metabolic risk factors for the highest mortality rates. Adverse trends in HBMI-associated mortality were observed, particularly in lower sociodemographic index (SDI) regions. HFPG-related mortality declined globally but increased in older age groups in lower SDI countries.
CONCLUSIONS: Despite a general decline in metabolic risk-related deaths in WAP, increasing HBMI- and HFPG-related mortality in lower SDI areas poses ongoing public health challenges. Developing nations should prioritize interventions addressing HBMI and HFPG to mitigate mortality risks in WAP.
METHODS: Data from the Global Burden of Disease 2019 study were leveraged to assess global metabolism-associated mortality and six key metabolic risk factors in WAP from 1990-2019. An age-period-cohort model was employed to determine the overall percentage change in mortality.
RESULTS: The 2019 global metabolic risk-related mortality rate in WAP rose significantly by 50.73%, while the age-standardized mortality rate declined by 21.5%. India, China, Indonesia, the USA, and the Russian Federation were the top contributing countries to mortality in WAP, accounting for 51.01% of the total. High systolic blood pressure (HSBP), high body mass index (HBMI), and high fasting plasma glucose (HFPG) were the top metabolic risk factors for the highest mortality rates. Adverse trends in HBMI-associated mortality were observed, particularly in lower sociodemographic index (SDI) regions. HFPG-related mortality declined globally but increased in older age groups in lower SDI countries.
CONCLUSIONS: Despite a general decline in metabolic risk-related deaths in WAP, increasing HBMI- and HFPG-related mortality in lower SDI areas poses ongoing public health challenges. Developing nations should prioritize interventions addressing HBMI and HFPG to mitigate mortality risks in WAP.
摘要：
背景：代谢疾病在全球范围内导致过早死亡，随着工作年龄人口(WAP)负担的增加。这项研究评估了全球，区域,以及WAP三十年来代谢紊乱和相关死亡率的国家趋势。
方法：利用2019年全球疾病负担研究的数据评估1990-2019年WAP中全球代谢相关死亡率和6个关键代谢危险因素。采用年龄-时期-队列模型来确定死亡率的总体百分比变化。
结果：WAP的2019年全球代谢风险相关死亡率显着上升了50.73％，而年龄标准化死亡率下降了21.5%。印度,中国,印度尼西亚,美国,俄罗斯联邦是WAP死亡率最高的国家，占总数的51.01%。高收缩压（HSBP），高体重指数（HBMI），高空腹血糖(HFPG)是死亡率最高的代谢危险因素.观察到HBMI相关死亡率的不良趋势，特别是在社会人口指数(SDI)较低的地区。HFPG相关死亡率在全球范围内有所下降，但在SDI较低国家的老年群体中有所上升。
结论：尽管WAP中与代谢风险相关的死亡人数普遍下降，在SDI较低地区,HBMI和HFPG相关死亡率的增加带来了持续的公共卫生挑战.发展中国家应优先考虑针对HBMI和HFPG的干预措施，以减轻WAP中的死亡风险。
方法：利用2019年全球疾病负担研究的数据评估1990-2019年WAP中全球代谢相关死亡率和6个关键代谢危险因素。采用年龄-时期-队列模型来确定死亡率的总体百分比变化。
结果：WAP的2019年全球代谢风险相关死亡率显着上升了50.73％，而年龄标准化死亡率下降了21.5%。印度,中国,印度尼西亚,美国,俄罗斯联邦是WAP死亡率最高的国家，占总数的51.01%。高收缩压（HSBP），高体重指数（HBMI），高空腹血糖(HFPG)是死亡率最高的代谢危险因素.观察到HBMI相关死亡率的不良趋势，特别是在社会人口指数(SDI)较低的地区。HFPG相关死亡率在全球范围内有所下降，但在SDI较低国家的老年群体中有所上升。
结论：尽管WAP中与代谢风险相关的死亡人数普遍下降，在SDI较低地区,HBMI和HFPG相关死亡率的增加带来了持续的公共卫生挑战.发展中国家应优先考虑针对HBMI和HFPG的干预措施，以减轻WAP中的死亡风险。
