Abstract：
Globally, cancer is a serious health problem. It is unfortunate that current anti-cancer strategies are insufficiently specific and damage the normal tissues. There\'s urgent need for development of new anti-cancer strategies. More recently, increasing attention has been paid to the new application of ferroptosis and nano materials in cancer research. Ferroptosis, a condition characterized by excessive reactive oxygen species-induced lipid peroxidation, as a new programmed cell death mode, exists in the process of a number of diseases, including cancers, neurodegenerative disease, cerebral hemorrhage, liver disease, and renal failure. There is growing evidence that inducing ferroptosis has proven to be an effective strategy against a variety of chemo-resistant cancer cells. Nano-drug delivery system based on nanotechnology provides a highly promising platform with the benefits of precise control of drug release and reduced toxicity and side effects. This paper reviews the latest advances of combination therapy strategies based on biomedical nanotechnology induced ferroptosis for cancer therapeutics. Given the new chances and challenges in this emerging area, we need more attention to the combination of nanotechnology and ferroptosis in the treatment of cancer in the future.
摘要：
全球范围内,癌症是一个严重的健康问题。不幸的是，目前的抗癌策略缺乏足够的特异性并损害正常组织。迫切需要开发新的抗癌策略。最近,铁凋亡和纳米材料在癌症研究中的新应用日益受到重视。Ferroptosis,一种以过度的活性氧引起的脂质过氧化为特征的疾病，作为一种新的程序性细胞死亡模式，存在于许多疾病的过程中，包括癌症,神经退行性疾病，脑出血,肝病,和肾衰竭。越来越多的证据表明，诱导铁凋亡已被证明是对抗多种化学抗性癌细胞的有效策略。基于纳米技术的纳米药物递送系统提供了一个非常有前途的平台，具有精确控制药物释放和减少毒性和副作用的优点。本文综述了基于生物医学纳米技术诱导的铁凋亡的联合治疗策略在癌症治疗中的最新进展。鉴于这一新兴领域面临新的机遇和挑战，在未来的癌症治疗中，我们需要更多的关注纳米技术和铁的结合。
