Abstract：
Inclusive thermal comfort solutions should accommodate the need of clinical groups such as people with Multiple Sclerosis (pwMS), who experience abnormal thermal sensitivity. The aim of this study was to develop high-density body maps of temperature sensitivity in pwMS to inform the design of patient-centred personal comfort systems. Fourteen pwMS (6 M/8 F; 48.6 ± 10.0 y) and 13 healthy individuals (CTR; 5 M/8 F; 47.8 ± 10.4) underwent a quantitative sensory test in a thermoneutral environment, during which they rated their local thermal sensations arising from the application of warm (39°C) and cold (27°C) stimuli to 115 bilateral body sites across the face, torso, upper and lower limbs. We used a z-transformation to create maps of hypo- and hyper-sensitivity for each individual MS participant using normative CTR data. We found that 50% of pwMS (N = 7/14) presented a loss of cold sensitivity over the upper limb, and a loss of warm sensitivity over the feet. Furthermore, 36% of pwMS (N = 5) presented warm hyper-sensitivity over the upper limb. Finally, cold sensitivity loss and warm sensitivity gain were more evenly distributed and affected a greater proportion of skin sites in MS (i.e. cold hypo-sensitivity = 44% of tested sites; warm hyper-sensitivity = 14%) than warm sensitivity loss (i.e. 10%), which was more focused on sites such as the feet. Our findings highlight the need to consider \"thermosensory corrective power\" when designing personal comfort systems, to accommodate either thermosensory loss or gain in pwMS. Our approach to clinical body mapping may support this process and help meeting the unique thermal needs of vulnerable individuals.
摘要：
包容性热舒适解决方案应适应临床群体的需求，如多发性硬化症患者（pwMS），经历异常热敏感性的人。这项研究的目的是开发pwMS中温度敏感性的高密度人体图，以告知以患者为中心的个人舒适系统的设计。14个pwMS（6M/8F;48.6±10.0y）和13个健康个体（CTR;5M/8F;47.8±10.4）在热中性环境中进行了定量感觉测试，在此期间，他们对面部115个双侧身体部位施加温暖（39°C）和寒冷（27°C）刺激引起的局部热感觉进行了评估，躯干,上肢和下肢。我们使用z变换使用规范的CTR数据为每个MS参与者创建低敏感度和高敏感度的图。我们发现50％的pwMS（N=7/14）表现为上肢的冷敏感性丧失，脚部失去了温暖的敏感性。此外，36％的pwMS（N=5）在上肢上表现出温暖的超敏感性。最后,冷敏感性损失和热敏感性增加分布更均匀，并影响更大比例的皮肤部位在MS（即冷敏感性=44％的测试部位;温暖的超敏感性=14％）比热敏感性损失（即10％），更专注于脚等部位。我们的发现强调了在设计个人舒适系统时需要考虑“热感矫正力”，以适应pwMS中的热感损失或增加。我们的临床身体测绘方法可以支持这一过程，并帮助满足脆弱个体的独特热需求。
