Abstract：
This article is an autobiographical account of a research career in inflammatory diseases, mechanisms and pharmacotherapy, drug research and development, in academia and industry in various European countries spanning the last 55 years. The author describes how tenacity and independent thought, learned in formative years, and tempered later by the development of good relationships with colleagues have guided his career. This has spanned research, among other fields, on prostaglandins as pro-and anti-inflammatory mediators, oxidative stress and antioxidants, phospholipid mediators, cytokines, innate and adaptive immune responses and the establishment of various inflammatory and immunological models. The author has helped discover and develop novel therapeutic approaches to pain, arthritic, dermatological, respiratory, and autoimmune disorders and contributed to bringing eight drug candidates to clinical trials. He has helped establish new research labs in four different centres and been involved in teaching undergraduate and mature students in three different universities. With extensive experience in scientific publishing and several international awards, he emphasises that without good teamwork, little can be achieved in scientific research.
摘要：
这篇文章是对炎症性疾病研究生涯的自传，机制和药物治疗，药物研发,在过去的55年里，在欧洲各个国家的学术界和工业界。作者描述了坚韧和独立思考，在成长的岁月里学到的，后来与同事的良好关系的发展也指导了他的职业生涯。这跨越了研究，在其他领域中，前列腺素作为促炎和抗炎介质，氧化应激和抗氧化剂，磷脂介质,细胞因子,先天和适应性免疫反应以及各种炎症和免疫模型的建立。作者帮助发现和开发了新的疼痛治疗方法，关节炎,皮肤病学,呼吸,和自身免疫性疾病，并促成了8种候选药物进入临床试验。他帮助在四个不同的中心建立了新的研究实验室，并参与了三所不同大学的本科生和成熟学生的教学。拥有丰富的科学出版经验和多个国际奖项，他强调，如果没有良好的团队合作，在科学研究中几乎没有什么成就。
