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Abstract：
Islet transplantation may be the most efficient therapeutic technique for patients with type 1 diabetes mellitus (T1DM). However, the clinical application of this method is faced with numerous limitations, including isolated islet apoptosis, recipient rejection, and graft vascular reconstruction. Mesenchymal stem cells (MSCs) possess anti-apoptotic, immunomodulatory, and angiogenic properties. Here, we review recent studies on co-culture and co-transplantation of islets with MSCs. We have summarized the methods of preparation of co-transplantation, especially the merits of co-culture, and the effects of co-transplantation. Accumulating experimental evidence shows that co-culture of islets with MSCs promotes islet survival, enhances islet secretory function, and prevascularizes islets through various pretransplant preparations. This review is expected to provide a reference for exploring the use of MSCs for clinical islet co-transplantation.
摘要：
胰岛移植可能是1型糖尿病（T1DM）患者最有效的治疗技术。然而,这种方法的临床应用面临着许多限制，包括孤立的胰岛细胞凋亡，收件人拒绝，和移植血管重建。间充质干细胞（MSCs）具有抗凋亡，免疫调节,和血管生成特性。这里,我们回顾了最近关于胰岛与MSCs共培养和共移植的研究。我们总结了共同移植的制备方法，特别是共同文化的优点，以及共同移植的效果。积累的实验证据表明，胰岛与MSCs共培养促进胰岛存活，增强胰岛分泌功能，并通过各种移植前的准备来促进胰岛的生长。本文旨在为探索MSCs在临床胰岛共移植中的应用提供参考。
