PDF(Pubmed)
Abstract：
The vagina hosts a community of microorganisms known as the vaginal microbiota. This community is relatively stable and straightforward, with Lactobacillus species being the most dominant members. The vaginal microbiota has various functions that are essential for maintaining human health and balance. For example, it can metabolise dietary nutrients, produce growth factors, communicate with other bacteria, modulate the immune system, and prevent the invasion of harmful pathogens. When the vaginal microbiota is disrupted, it can lead to diseases and infections. The observed disturbance is distinguished by a reduction in the prevalence of Lactobacillus and a concurrent rise in the number of other bacterial species that exhibit a higher tolerance to low oxygen levels. Gynecologic cancers are a group of cancers that affect the female reproductive organs and tissues, such as the ovaries, uterus, cervix, vagina, vulva, and endometrium. These cancers are a major global health problem for women. Understanding the complex interactions between the host and the vaginal microorganisms may provide new insights into the prevention and treatment of gynecologic cancers. This could improve the quality of life and health outcomes for women.
摘要：
阴道拥有称为阴道微生物群的微生物群落。这个社区相对稳定和直接，乳杆菌是最主要的成员。阴道微生物群具有维持人体健康和平衡所必需的各种功能。例如,它可以代谢膳食营养素，产生生长因子，与其他细菌交流，调节免疫系统，并防止有害病原体的入侵。当阴道微生物群被破坏时，它会导致疾病和感染。观察到的干扰的特征是乳杆菌的流行率降低，而对低氧水平表现出更高耐受性的其他细菌种类的数量同时增加。妇科癌症是一组影响女性生殖器官和组织的癌症，比如卵巢，子宫,子宫颈,阴道,外阴,还有子宫内膜.这些癌症是妇女面临的主要全球健康问题。了解宿主与阴道微生物之间的复杂相互作用可能为妇科癌症的预防和治疗提供新的见解。这可以改善妇女的生活质量和健康结果。
