PDF(Pubmed)
Abstract：
Carbapenem-resistant Klebsiella pneumoniae (CRKP) are of particular concern due to the spread of antibiotic resistance genes associated with mobile genetic elements. In this study, we collected 687 carbapenem-resistant strains recovered among clinical samples from 41 hospitals in nine Southern European countries (2016-2018). We identified 11 major clonal lineages, with most isolates belonging to the high-risk clones ST258/512, ST101, ST11, and ST307. blaKPC-like was the most prevalent carbapenemase-encoding gene (46%), with blaOXA-48 present in 39% of isolates. Through the combination and comparison of this EURECA collection with the previous EuSCAPE collection (2013-2014), we investigated the spread of high-risk clones circulating in Europe exhibiting regional differences. We particularly found blaKPC-like ST258/512 in Greece, Italy, and Spain, blaOXA-48 ST101 in Serbia and Romania, blaNDM ST11 in Greece, and blaOXA-48-like ST14 in Türkiye. Genomic surveillance across Europe thus provides crucial insights for local risk mapping and informs necessary adaptions for implementation of control strategies.
摘要：
由于与可移动遗传元件相关的抗生素抗性基因的传播，耐碳青霉烯类肺炎克雷伯菌（CRKP）尤其受到关注。在这项研究中,我们从9个南欧国家(2016-2018年)的41家医院的临床样本中收集了687株碳青霉烯类耐药菌株.我们鉴定了11个主要的克隆谱系,大多数分离株属于高风险克隆ST258/512，ST101，ST11和ST307。blaKPC样是最普遍的碳青霉烯酶编码基因(46%)，在39%的分离物中存在blaOXA-48。通过将此EURECA系列与以前的EuSCAPE系列（2013-2014）进行组合和比较，我们调查了在欧洲传播的高风险克隆的传播，这些克隆具有区域差异。我们特别在希腊发现了类似blaKPC的ST258/512，意大利,西班牙,blaOXA-48ST101在塞尔维亚和罗马尼亚，blaNDMST11在希腊,还有Türkiye的blaOXA-48-likeST14.因此，整个欧洲的基因组监测为本地风险图谱提供了重要的见解，并为实施控制策略提供了必要的调整。
