%0 Journal Article
%T International and regional spread of carbapenem-resistant Klebsiella pneumoniae in Europe.
%A Budia-Silva M
%A Kostyanev T
%A Ayala-Montaño S
%A Bravo-Ferrer Acosta J
%A Garcia-Castillo M
%A Cantón R
%A Goossens H
%A Rodriguez-Baño J
%A Grundmann H
%A Reuter S
%J Nat Commun
%V 15
%N 1
%D 2024 Jun 14
%M 38877000
%F 17.694
%R 10.1038/s41467-024-49349-z
%X Carbapenem-resistant Klebsiella pneumoniae (CRKP) are of particular concern due to the spread of antibiotic resistance genes associated with mobile genetic elements. In this study, we collected 687 carbapenem-resistant strains recovered among clinical samples from 41 hospitals in nine Southern European countries (2016-2018). We identified 11 major clonal lineages, with most isolates belonging to the high-risk clones ST258/512, ST101, ST11, and ST307. blaKPC-like was the most prevalent carbapenemase-encoding gene (46%), with blaOXA-48 present in 39% of isolates. Through the combination and comparison of this EURECA collection with the previous EuSCAPE collection (2013-2014), we investigated the spread of high-risk clones circulating in Europe exhibiting regional differences. We particularly found blaKPC-like ST258/512 in Greece, Italy, and Spain, blaOXA-48 ST101 in Serbia and Romania, blaNDM ST11 in Greece, and blaOXA-48-like ST14 in Türkiye. Genomic surveillance across Europe thus provides crucial insights for local risk mapping and informs necessary adaptions for implementation of control strategies.