Abstract：
Hematopoietic stem and progenitor cells (HSPCs) can give rise to all kinds of immune cells including neutrophils. Neutrophils are the first line of defense in the innate immune system with a short lifespan, due to which it is well-accepted that neutrophils have no immune memory. However, recent reports showed that the changes in HSPCs induced by primary stimulation could last a long time, which contributes to enhancing response to subsequent infection by generating more monocytes or macrophages equipped with stronger anti-bacterial function. Here, we used the reinfection mice model to reveal that primary infection could improve neutrophil-mediated host defense by training neutrophil progenitors in mammals, providing a new idea to enhance neutrophil number and improve neutrophil functions, which is pretty pivotal for patients with compromised or disordered immunity.
摘要：
造血干细胞和祖细胞（HSPCs）可以产生各种免疫细胞，包括中性粒细胞。中性粒细胞是先天免疫系统的第一道防线，寿命很短，因此，中性粒细胞没有免疫记忆是公认的。然而,最近的报道表明，由初级刺激引起的HSPCs的变化可以持续很长时间，这有助于通过产生更多具有更强抗菌功能的单核细胞或巨噬细胞来增强对随后感染的反应。这里,我们使用再感染小鼠模型揭示了初级感染可以通过训练哺乳动物的中性粒细胞祖细胞来改善中性粒细胞介导的宿主防御，提供了一种提高中性粒细胞数量和改善中性粒细胞功能的新思路，这对于免疫力受损或紊乱的患者来说非常关键。
