{Reference Type}: Journal Article
{Title}: Primary infection enhances neutrophil-mediated host defense by educating HSPCs.
{Author}: Wu P;Zhang Q;Xu X;He S;Liu Z;Li Y;Guo R;
{Journal}: Int Immunopharmacol
{Volume}: 137
{Issue}: 0
{Year}: 2024 Aug 20
{Factor}: 5.714
{DOI}: 10.1016/j.intimp.2024.112382
{Abstract}: Hematopoietic stem and progenitor cells (HSPCs) can give rise to all kinds of immune cells including neutrophils. Neutrophils are the first line of defense in the innate immune system with a short lifespan, due to which it is well-accepted that neutrophils have no immune memory. However, recent reports showed that the changes in HSPCs induced by primary stimulation could last a long time, which contributes to enhancing response to subsequent infection by generating more monocytes or macrophages equipped with stronger anti-bacterial function. Here, we used the reinfection mice model to reveal that primary infection could improve neutrophil-mediated host defense by training neutrophil progenitors in mammals, providing a new idea to enhance neutrophil number and improve neutrophil functions, which is pretty pivotal for patients with compromised or disordered immunity.