Abstract：
Obsessive-compulsive disorder (OCD) affects 2-3% of people worldwide. Although antidepressants are the standard pharmachological treatment of OCD, their effect on the brain of individuals with OCD has not yet been fully clarified. We conducted a systematic search on PubMed, Scopus, Embase, and Web of Science to explore the effects of antidepressants on neuroimaging findings in OCD. Thirteen neuroimaging investigations were included. After antidepressant treatment, structural magnetic resonance imaging studies suggested thalamic, amygdala, and pituitary volume changes in patients. In addition, the use of antidepressants was associated with alterations in diffusion tensor imaging metrics in the left striatum, the right midbrain, and the posterior thalamic radiation in the right parietal lobe. Finally, functional magnetic resonance imaging highlighted possible changes in the ventral striatum, frontal, and prefrontal cortex. The small number of included studies and sample sizes, short durations of follow-up, different antidepressants, variable regions of interest, and heterogeneous samples limit the robustness of the findings of the present review. In conclusion, our review suggests that antidepressant treatment is associated with brain changes in individuals with OCD, and these results may help to deepen our knowledge of the pathophysiology of OCD and the brain mechanisms underlying the effects of antidepressants.
摘要：
强迫症（OCD）影响全球2-3％的人。虽然抗抑郁药是强迫症的标准药物治疗，它们对强迫症患者大脑的影响尚未完全阐明。我们在PubMed上进行了系统的搜索,Scopus,Embase,和WebofScience探索抗抑郁药对强迫症神经影像学检查结果的影响。包括13项神经影像学检查。抗抑郁治疗后,结构磁共振成像研究建议丘脑，杏仁核,和患者的垂体体积变化。此外,抗抑郁药的使用与左纹状体扩散张量成像指标的改变有关,右中脑，和右顶叶的后丘脑辐射。最后,功能磁共振成像突出了腹侧纹状体的可能变化，额叶,和前额叶皮层.纳入的研究和样本量少，短期随访，不同的抗抑郁药，感兴趣的可变区域，和异质样本限制了本综述研究结果的稳健性。总之,我们的审查表明，抗抑郁治疗与强迫症患者的大脑变化有关，这些结果可能有助于加深我们对强迫症的病理生理学和抗抑郁药作用的脑机制的认识。
