OBJECTIVE: We investigated the relationship of CO (without associated disorders) with left ventricular (LV) characteristics and intrathoracic adipose tissue (IAT) by cardiac magnetic resonance.
METHODS: LV characteristics, epicardial (EAT), and mediastinal adipose tissue (MAT) were measured from 29 normoglycemic, normotensive males with CO but without general obesity (waist circumference >100 cm, body mass index (BMI) <30 kg/m2) and 18 non-obese male controls.
RESULTS: LV maximal wall thickness (LVMWT) and IAT but not LV mass or volumes were increased in CO subjects compared to controls (LVMWT, 12.3±1.2 vs. 10.7±1.5 mm, p < 0.001; EAT, 5.5±3.0 vs. 2.2±2.0 cm2, p = 0.001; MAT, 31.0±12.8 vs. 15.4±10.7 cm2, p < 0.001). The LVMWT was ≥12 mm in 69% of subjects with CO and 22% of controls (p = 0.002). In CO suspects, EAT correlated inversely with LV end-diastolic volume index (r = - 0.403, p = 0.037) and LV stroke volume (SV) (r = - 0.425, p = 0.027). MAT correlated inversely with SV (r = - 0.427, p=0.026) and positively with LVMWT (r = 0.399, p = 0.035). Among CO subjects, the waist-to-hip ratio (WHR) was an independent predictor of LVMWT (B = 22.4, β = 0.617, p < 0.001). The optimal cut-off with Youden\'s index for LV hypertrophy was identified at WHR 0.98 (sensitivity 85%, specificity 89%).
CONCLUSIONS: CO independent of BMI is associated with LV hypertrophy and intrathoracic adipose tissue contributing to cardiovascular burden.
目的:我们通过心脏磁共振研究了CO(无相关疾病)与左心室(LV)特征和胸内脂肪组织(IAT)的关系。
方法:LV特征,心外膜(EAT),和纵隔脂肪组织(MAT)从29例血糖正常,血压正常的男性有CO但没有一般肥胖(腰围>100厘米,体重指数(BMI)<30kg/m2)和18名非肥胖男性对照。
结果:与对照组相比,CO受试者的LV最大壁厚(LVMWT)和IAT而不是LV质量或体积增加(LVMWT,12.3±1.2vs.10.7±1.5mm,p<0.001;EAT,5.5±3.0vs.2.2±2.0cm2,p=0.001;MAT,31.0±12.8vs.15.4±10.7cm2,p<0.001)。在69%的CO受试者和22%的对照组中,LVMWT≥12mm(p=0.002)。在共同嫌疑犯中,EAT与左心室舒张末期容积指数(r=-0.403,p=0.037)和左心室每搏输出量(SV)(r=-0.425,p=0.027)呈负相关。MAT与SV呈负相关(r=-0.427,p=0.026),与LVMWT呈正相关(r=0.399,p=0.035)。在CO受试者中,腰臀比(WHR)是LVMWT的独立预测因子(B=22.4,β=0.617,p<0.001)。在WHR0.98时确定了Youden指数对LV肥大的最佳截止值(灵敏度为85%,特异性89%)。
结论:与BMI无关的CO与左心室肥大和胸腔内脂肪组织导致心血管负担相关。