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Abstract：
BACKGROUND: Central obesity (CO), characterized by an increased waist circumference increases the risk of cardiovascular disease (CVD) and morbidity, yet the underlying mechanisms are not fully understood. CO is often associated with general obesity, hypertension, and abnormal glucose tolerance, confounding the independent contribution of CO to CVD.
OBJECTIVE: We investigated the relationship of CO (without associated disorders) with left ventricular (LV) characteristics and intrathoracic adipose tissue (IAT) by cardiac magnetic resonance.
METHODS: LV characteristics, epicardial (EAT), and mediastinal adipose tissue (MAT) were measured from 29 normoglycemic, normotensive males with CO but without general obesity (waist circumference >100 cm, body mass index (BMI) <30 kg/m2) and 18 non-obese male controls.
RESULTS: LV maximal wall thickness (LVMWT) and IAT but not LV mass or volumes were increased in CO subjects compared to controls (LVMWT, 12.3±1.2 vs. 10.7±1.5 mm, p < 0.001; EAT, 5.5±3.0 vs. 2.2±2.0 cm2, p = 0.001; MAT, 31.0±12.8 vs. 15.4±10.7 cm2, p < 0.001). The LVMWT was ≥12 mm in 69% of subjects with CO and 22% of controls (p = 0.002). In CO suspects, EAT correlated inversely with LV end-diastolic volume index (r = - 0.403, p = 0.037) and LV stroke volume (SV) (r = - 0.425, p = 0.027). MAT correlated inversely with SV (r = - 0.427, p=0.026) and positively with LVMWT (r = 0.399, p = 0.035). Among CO subjects, the waist-to-hip ratio (WHR) was an independent predictor of LVMWT (B = 22.4, β = 0.617, p < 0.001). The optimal cut-off with Youden\'s index for LV hypertrophy was identified at WHR 0.98 (sensitivity 85%, specificity 89%).
CONCLUSIONS: CO independent of BMI is associated with LV hypertrophy and intrathoracic adipose tissue contributing to cardiovascular burden.
OBJECTIVE: We investigated the relationship of CO (without associated disorders) with left ventricular (LV) characteristics and intrathoracic adipose tissue (IAT) by cardiac magnetic resonance.
METHODS: LV characteristics, epicardial (EAT), and mediastinal adipose tissue (MAT) were measured from 29 normoglycemic, normotensive males with CO but without general obesity (waist circumference >100 cm, body mass index (BMI) <30 kg/m2) and 18 non-obese male controls.
RESULTS: LV maximal wall thickness (LVMWT) and IAT but not LV mass or volumes were increased in CO subjects compared to controls (LVMWT, 12.3±1.2 vs. 10.7±1.5 mm, p < 0.001; EAT, 5.5±3.0 vs. 2.2±2.0 cm2, p = 0.001; MAT, 31.0±12.8 vs. 15.4±10.7 cm2, p < 0.001). The LVMWT was ≥12 mm in 69% of subjects with CO and 22% of controls (p = 0.002). In CO suspects, EAT correlated inversely with LV end-diastolic volume index (r = - 0.403, p = 0.037) and LV stroke volume (SV) (r = - 0.425, p = 0.027). MAT correlated inversely with SV (r = - 0.427, p=0.026) and positively with LVMWT (r = 0.399, p = 0.035). Among CO subjects, the waist-to-hip ratio (WHR) was an independent predictor of LVMWT (B = 22.4, β = 0.617, p < 0.001). The optimal cut-off with Youden\'s index for LV hypertrophy was identified at WHR 0.98 (sensitivity 85%, specificity 89%).
CONCLUSIONS: CO independent of BMI is associated with LV hypertrophy and intrathoracic adipose tissue contributing to cardiovascular burden.
摘要：
背景：中心性肥胖（CO），以腰围增加为特征的心血管疾病（CVD）和发病率的风险增加，然而，潜在的机制还没有完全理解。一氧化碳通常与一般肥胖有关，高血压,和糖耐量异常,混淆了CO对CVD的独立贡献。
目的：我们通过心脏磁共振研究了CO（无相关疾病）与左心室（LV）特征和胸内脂肪组织（IAT）的关系。
方法：LV特征，心外膜(EAT),和纵隔脂肪组织（MAT）从29例血糖正常，血压正常的男性有CO但没有一般肥胖(腰围>100厘米，体重指数（BMI）<30kg/m2）和18名非肥胖男性对照。
结果：与对照组相比，CO受试者的LV最大壁厚（LVMWT）和IAT而不是LV质量或体积增加（LVMWT，12.3±1.2vs.10.7±1.5mm,p<0.001;EAT,5.5±3.0vs.2.2±2.0cm2,p=0.001;MAT,31.0±12.8vs.15.4±10.7cm2，p<0.001）。在69％的CO受试者和22％的对照组中，LVMWT≥12mm（p=0.002）。在共同嫌疑犯中，EAT与左心室舒张末期容积指数（r=-0.403，p=0.037）和左心室每搏输出量（SV）（r=-0.425，p=0.027）呈负相关。MAT与SV呈负相关（r=-0.427，p=0.026），与LVMWT呈正相关（r=0.399，p=0.035）。在CO受试者中，腰臀比(WHR)是LVMWT的独立预测因子(B=22.4,β=0.617,p<0.001)。在WHR0.98时确定了Youden指数对LV肥大的最佳截止值（灵敏度为85％，特异性89%)。
结论：与BMI无关的CO与左心室肥大和胸腔内脂肪组织导致心血管负担相关。
目的：我们通过心脏磁共振研究了CO（无相关疾病）与左心室（LV）特征和胸内脂肪组织（IAT）的关系。
方法：LV特征，心外膜(EAT),和纵隔脂肪组织（MAT）从29例血糖正常，血压正常的男性有CO但没有一般肥胖(腰围>100厘米，体重指数（BMI）<30kg/m2）和18名非肥胖男性对照。
结果：与对照组相比，CO受试者的LV最大壁厚（LVMWT）和IAT而不是LV质量或体积增加（LVMWT，12.3±1.2vs.10.7±1.5mm,p<0.001;EAT,5.5±3.0vs.2.2±2.0cm2,p=0.001;MAT,31.0±12.8vs.15.4±10.7cm2，p<0.001）。在69％的CO受试者和22％的对照组中，LVMWT≥12mm（p=0.002）。在共同嫌疑犯中，EAT与左心室舒张末期容积指数（r=-0.403，p=0.037）和左心室每搏输出量（SV）（r=-0.425，p=0.027）呈负相关。MAT与SV呈负相关（r=-0.427，p=0.026），与LVMWT呈正相关（r=0.399，p=0.035）。在CO受试者中，腰臀比(WHR)是LVMWT的独立预测因子(B=22.4,β=0.617,p<0.001)。在WHR0.98时确定了Youden指数对LV肥大的最佳截止值（灵敏度为85％，特异性89%)。
结论：与BMI无关的CO与左心室肥大和胸腔内脂肪组织导致心血管负担相关。
