Abstract：
Infectious diseases caused by bacterial, viral, and fungal pathogens present significant global health challenges. The rapid emergence of antimicrobial resistance exacerbates this issue, leading to a scenario where effective antibiotics are increasingly scarce. Traditional antibiotic development strategies are proving inadequate against the swift evolution of microbial resistance. Therefore, there is an urgent need to develop novel antimicrobial strategies with mechanisms distinct from those of existing antibiotics. Nanozybiotics, which are nanozyme-based antimicrobials, mimic the catalytic action of lysosomal enzymes in innate immune cells to kill infectious pathogens. This review reinforces the concept of nanozymes and provides a comprehensive summary of recent research advancements on potential antimicrobial candidates. Initially, nanozybiotics are categorized based on their activities, mimicking either oxidoreductase-like or hydrolase-like functions, thereby highlighting their superior mechanisms in combating antimicrobial resistance. The review then discusses the progress of nanozybiotics in treating bacterial, viral, and fungal infections, confirming their potential as novel antimicrobial candidates. The translational potential of nanozybiotic-based products, including hydrogels, nanorobots, sprays, bandages, masks, and protective clothing, is also considered. Finally, the current challenges and future prospects of nanozybiotic-related products are explored, emphasizing the design and antimicrobial capabilities of nanozybiotics for future applications.
摘要：
由细菌引起的传染病，病毒，和真菌病原体带来了重大的全球健康挑战。抗生素耐药性的迅速出现加剧了这个问题，导致有效抗生素越来越稀缺的情况。传统的抗生素开发策略被证明不足以抵抗微生物抗性的快速进化。因此,迫切需要开发具有不同于现有抗生素的机制的新型抗菌策略.纳米酶，是基于纳米酶的抗菌剂，模拟溶酶体酶在先天免疫细胞中的催化作用，以杀死感染性病原体。这篇综述加强了纳米酶的概念，并对潜在的抗微生物候选物的最新研究进展进行了全面总结。最初，纳米酶根据它们的活性进行分类，模拟氧化还原酶样或水解酶样功能，从而突出了他们在对抗抗生素耐药性方面的优越机制。然后，本文讨论了纳米酶在治疗细菌方面的进展，病毒，和真菌感染，证实了它们作为新型抗菌候选药物的潜力。基于纳米酶的产品的翻译潜力，包括水凝胶，纳米机器人,喷雾剂,绷带,面具,和防护服，也考虑到了。最后,探讨了纳米酶相关产品的当前挑战和未来前景，强调未来应用纳米酶的设计和抗菌能力。本文受版权保护。保留所有权利。
