Abstract：
Major depressive disorder (MDD) patients\' personality traits and illness representations are linked to MDD severity. However, the associations between personality and illness representations in MDD and the mediating role of illness representations between personality and MDD severity have not been investigated. This study aimed to prospectively investigate the aforementioned associations and the possible mediating role of illness representations between personality and MDD severity. One hundred twenty-five patients with a MDD diagnosis, aged 48.18 ± 13.92 (84% females), participated in the study. Personality traits were measured with the Traits Personality Questionnaire at baseline. Illness representations were measured with the Illness Perception Questionnaire-Mental Health about five months later (mean = 5.08 ± 1.14 months). MDD severity was measured about 10 months after the baseline assessment (mean = 9.53 ± 2.36 months) with the Beck Depression Inventory. SPSS 29 and AMOS 27 were used to conduct correlational and parallel mediation analyses. According to the results, Neuroticism was positively and Extraversion was negatively linked to MDD severity. Negative MDD impact representations fully mediated these associations. Neuroticism and Extraversion are linked to future MDD severity through patients\' representations of MDD\'s impact. Restructuring maladaptive representations about MDD\'s impact can be a promising way to reduce symptom severity in patients with high Neuroticism and low Extraversion levels.
摘要：
重度抑郁症（MDD）患者的人格特征和疾病表现与MDD严重程度有关。然而,尚未研究MDD中人格与疾病表征之间的关联以及疾病表征在人格与MDD严重程度之间的中介作用.这项研究旨在前瞻性地调查上述关联以及疾病表征在人格和MDD严重程度之间的可能中介作用。125名诊断为MDD的患者，48.18±13.92岁(84%为女性)，参与研究。在基线时用特质人格问卷测量人格特征。大约五个月后，用疾病感知问卷-心理健康测量疾病表现（平均值=5.08±1.14个月）。在基线评估后约10个月(平均=9.53±2.36个月)用贝克抑郁量表测量MDD严重程度。使用SPSS29和AMOS27进行相关和并行调解分析。根据结果,神经质呈正相关，外向性与MDD严重程度呈负相关。负MDD影响表示完全介导了这些关联。神经质和外向性通过患者对MDD影响的表征与未来MDD的严重程度相关。重组关于MDD影响的适应不良表示可能是降低高神经质和低外向水平患者症状严重程度的有希望的方法。
