PDF(Pubmed)
Abstract：
OBJECTIVE: To estimate the pterygium ocular surface state, and compare with healthy eyes and dry eyes. To investigate the inflammation due to pterygia growth by tear Lymphotoxin-alpha (LT α) test.
METHODS: Prospective, single-center study.
METHODS: 400 patients, divided into 100 pterygium group, 100 mild dry eye group, 100 moderate dry eye group, and 100 age-and sex-matched normal controls.
METHODS: The non-invasive break-up time (NIBUT), tear meniscus height (TMH) test, corneal fluorescein staining (CFS), meibomian gland loss score (MGs), and lipid layer thickness (LLT) were evaluated in all patients. Pterygium status and ocular status in the pterygium group were collected. The tear LT α test was conducted in the pterygium patients group.
RESULTS: Pterygium can affect the ocular surface, leading to decreased tear film stability. The TMH, NIBUT, CFS, MGs, and lipid layer thickness can provide insights into this phenomenon. The presence of pterygium can change the structure and condition of the ocular surface. Tear LT α testing shows an abnormal decrease in LT α levels in pterygium patients. This indicates an immune-inflammation microenvironment that causes tissue repair deficiency.
CONCLUSIONS: The dry eye triggered by the growth of pterygium may originate from the tear film instability due to pterygia. As an inflammatory index, LT α in the development of pterygium and the aggravation of dry eye patients can indicate that the ocular surface is in different inflammatory states. Future tear testing in LT α may be a potential indicator to assess the inflammatory status of the dry eye.
METHODS: Prospective, single-center study.
METHODS: 400 patients, divided into 100 pterygium group, 100 mild dry eye group, 100 moderate dry eye group, and 100 age-and sex-matched normal controls.
METHODS: The non-invasive break-up time (NIBUT), tear meniscus height (TMH) test, corneal fluorescein staining (CFS), meibomian gland loss score (MGs), and lipid layer thickness (LLT) were evaluated in all patients. Pterygium status and ocular status in the pterygium group were collected. The tear LT α test was conducted in the pterygium patients group.
RESULTS: Pterygium can affect the ocular surface, leading to decreased tear film stability. The TMH, NIBUT, CFS, MGs, and lipid layer thickness can provide insights into this phenomenon. The presence of pterygium can change the structure and condition of the ocular surface. Tear LT α testing shows an abnormal decrease in LT α levels in pterygium patients. This indicates an immune-inflammation microenvironment that causes tissue repair deficiency.
CONCLUSIONS: The dry eye triggered by the growth of pterygium may originate from the tear film instability due to pterygia. As an inflammatory index, LT α in the development of pterygium and the aggravation of dry eye patients can indicate that the ocular surface is in different inflammatory states. Future tear testing in LT α may be a potential indicator to assess the inflammatory status of the dry eye.
摘要：
目的：评估翼状胬肉的眼表状态，并与健康的眼睛和干眼进行比较。通过泪液毒素α（LTα）试验探讨翼状胬肉生长引起的炎症。
方法：前瞻性，单中心研究。
方法：400名患者，分为100例翼状胬肉组，100轻度干眼症组，100中度干眼症组，和100个年龄和性别匹配的正常对照。
方法：非侵入性破裂时间（NIBUT），撕裂弯月面高度(TMH)试验,角膜荧光素染色（CFS），睑板腺丢失评分（MGs），并对所有患者进行脂质层厚度（LLT）评估。收集翼状胬肉组的翼状胬肉状态和眼部状态。翼状胬肉患者组进行泪液LTα试验。
结果：翼状胬肉可影响眼表，导致泪膜稳定性下降。TMH,NIBUT,CFS,MGs,和脂质层厚度可以提供对这一现象的见解。翼状胬肉的存在可以改变眼表的结构和状况。泪液LTα检测显示翼状胬肉患者LTα水平异常降低。这表明导致组织修复缺陷的免疫炎症微环境。
结论：翼状胬肉生长引发的干眼可能源于翼状胬肉引起的泪膜不稳定。作为炎症指标,LTα在翼状胬肉的发展和干眼患者的加重中可以表明眼表处于不同的炎症状态。LTα的未来泪液测试可能是评估干眼症炎症状态的潜在指标。
方法：前瞻性，单中心研究。
方法：400名患者，分为100例翼状胬肉组，100轻度干眼症组，100中度干眼症组，和100个年龄和性别匹配的正常对照。
方法：非侵入性破裂时间（NIBUT），撕裂弯月面高度(TMH)试验,角膜荧光素染色（CFS），睑板腺丢失评分（MGs），并对所有患者进行脂质层厚度（LLT）评估。收集翼状胬肉组的翼状胬肉状态和眼部状态。翼状胬肉患者组进行泪液LTα试验。
结果：翼状胬肉可影响眼表，导致泪膜稳定性下降。TMH,NIBUT,CFS,MGs,和脂质层厚度可以提供对这一现象的见解。翼状胬肉的存在可以改变眼表的结构和状况。泪液LTα检测显示翼状胬肉患者LTα水平异常降低。这表明导致组织修复缺陷的免疫炎症微环境。
结论：翼状胬肉生长引发的干眼可能源于翼状胬肉引起的泪膜不稳定。作为炎症指标,LTα在翼状胬肉的发展和干眼患者的加重中可以表明眼表处于不同的炎症状态。LTα的未来泪液测试可能是评估干眼症炎症状态的潜在指标。
