PDF(Pubmed)
Abstract：
Newly arrived refugees offer insights into malaria epidemiology in their countries of origin. We evaluated asymptomatic refugee children within 7 days of arrival in Uganda from South Sudan and the Democratic Republic of Congo (DRC) in 2022 for parasitemia, parasite species, and Plasmodium falciparum drug resistance markers. Asymptomatic P. falciparum infections were common in both populations. Coinfection with P. malariae was more common in DRC refugees. Prevalences of markers of aminoquinoline resistance (PfCRT K76T, PfMDR1 N86Y) were much higher in South Sudan refugees, of antifolate resistance (PfDHFR C59R and I164L, PfDHPS A437G, K540E, and A581G) much higher in DRC refugees, and of artemisinin partial resistance (ART-R; PfK13 C469Y and A675V) moderate in both populations. Prevalences of most mutations differed from those seen in Ugandans attending health centers near the refugee centers. Refugee evaluations yielded insights into varied malaria epidemiology and identified markers of ART-R in 2 previously little-studied countries.
摘要：
新来的难民提供了对原籍国疟疾流行病学的见解。我们在2022年从南苏丹和刚果民主共和国（DRC）抵达乌干达后7天内评估了无症状难民儿童的寄生虫血症。寄生虫物种，和恶性疟原虫耐药标记。无症状的恶性疟原虫感染在两个人群中都很常见。与疟原虫共感染在刚果民主共和国难民中更为常见。氨基喹啉抗性标记的流行(PfCRTK76T，PfMDR1N86Y）在南苏丹难民中高得多，抗叶酸药物抗性(PfDHFRC59R和I164L，PfDHPSA437G和K540E）在刚果民主共和国难民中高得多，青蒿素部分抗性（ART-R；PfK13C469Y和A675V）在两个人群中均中等。大多数突变的患病率与在难民中心附近的医疗中心就诊的乌干达人不同。难民评估产生了对各种疟疾流行病学的见解，并在两个以前很少研究的国家中确定了ART-R的标志物。
