Detection of carbapenemase producing Acinetobacter baumannii ST19 from Georgia and Ukraine carrying bla OXA-23, bla OXA-72, and/or bla NDM-5, December 2019 to June 2023.

2019 年 12 月至 2023 年 6 月 ， 检测来自格鲁吉亚和乌克兰的碳青霉烯酶产生鲍曼不动杆菌 ST19 ， 携带 bla OXA - 23 ， bla OXA - 72 和 / 或 bla NDM - 5 。

• 影响指数: 21.286
• 发表时间: 2024 Jun
• 来源期刊: Euro Surveill
• DOI: 10.2807/1560-7917.ES.2024.29.24.2400259
• PMID: 38873796
• 文章类型: Journal Article
• 中科院分区: Q1
• 方向: 医学
• 作者列表: Luo TL,Martin MJ,Kovalchuk V,Kondratiuk V,Trapaidze N,Metreveli M,Hulseberg CE,Dao HD,Kwak YI,Maybank R,Musich TA,Scherer MR,Bennett JW,Mc Gann PT,Lebreton F

关键词: A. baumannii; Acinetobacter baumannii; NDM; antimicrobial resistance; carbapenem resistance; microbial genomics; molecular epidemiology; nosocomial outbreak; surveillance

Mesh: beta-Lactamases / genetics; Acinetobacter baumannii / genetics isolation & purification drug effects enzymology; Humans; Acinetobacter Infections / microbiology epidemiology; Bacterial Proteins / genetics; Ukraine / epidemiology; Microbial Sensitivity Tests; Anti-Bacterial Agents / pharmacology; Carbapenems / pharmacology; Phylogeny; Drug Resistance, Multiple, Bacterial / genetics; Georgia (Republic) / epidemiology; Multilocus Sequence Typing

Abstract

In 2003-2023, amid 5,436 Acinetobacter baumannii isolates collected globally through the Multidrug-Resistant Organism Repository and Surveillance Network, 97 were ST19PAS, 34 of which carbapenem-resistant. Strains (n = 32) sampled after 2019 harboured either bla OXA-23, bla OXA-72, and/or bla NDM-5. Phylogenetic analysis of the 97 isolates and 11 publicly available ST19 genomes revealed three sub-lineages of carbapenemase-producing isolates from mainly Ukraine and Georgia, including an epidemic clone carrying all three carbapenemase genes. Infection control and global surveillance of carbapenem-resistant A. baumannii remain important.

摘要

2003-2023年，在通过多重耐药生物体存储和监测网络全球收集的5,436株鲍曼不动杆菌中，97是ST19PAS，34其中耐碳青霉烯。2019年后取样的菌株(n=32)含有blaOXA-23、blaOXA-72和/或blaNDM-5。对97个分离株和11个公开可用的ST19基因组的系统发育分析显示，主要来自乌克兰和格鲁吉亚的碳青霉烯酶产生分离株的三个亚谱系，包括一个携带所有三个碳青霉烯酶基因的流行病克隆。耐碳青霉烯鲍曼不动杆菌的感染控制和全球监测仍然很重要。