PDF(Pubmed)
Abstract：
UNASSIGNED: To determine the functional domains and symptom scales that affect patients most following radical cystectomy (RC) and urinary diversion (UD), and if a single instrument (or combination) adequately captures these bothersome symptoms. It is unclear whether current patient reported outcome (PRO) instruments that have been used to assess quality of life in patients following RC and UD adequately cover the most bothersome symptoms affecting patients.
UNASSIGNED: A systematic search of MEDLINE, EMBASE, PubMed, Cinahl and Cochrane was conducted from January 2000 to May 2023 for original articles of patients who had RC and UD since 2000 for muscle invasive bladder cancer. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) process was followed. Extracted data included the PRO measures used, domains reported and scores in the first 12 months post-surgery (short-term) and after 12 months (long-term). A conservative threshold of <70 for functional domains and >30 for symptom domains was used to determine which PRO domains were potentially concerning to patients in each study. Quality assessment was performed using the QUALSYST appraisal tool.
UNASSIGNED: Thirty-five studies met the inclusion criteria, including a total of eight unique PRO instruments. The main findings indicated that physical function was the most concerning PRO for patients with both neobladder (NB) and ileal conduit (IC) in the short and long term. Additionally, bowel, urinary and sexual bother were concerning symptoms for patients with NB in the long-term, but only in the short-term for those with IC.
UNASSIGNED: The main issues are adequately addressed using the combination of EORTC QLQ-C30 and QLQ-BLM30 instruments.
UNASSIGNED: A systematic search of MEDLINE, EMBASE, PubMed, Cinahl and Cochrane was conducted from January 2000 to May 2023 for original articles of patients who had RC and UD since 2000 for muscle invasive bladder cancer. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) process was followed. Extracted data included the PRO measures used, domains reported and scores in the first 12 months post-surgery (short-term) and after 12 months (long-term). A conservative threshold of <70 for functional domains and >30 for symptom domains was used to determine which PRO domains were potentially concerning to patients in each study. Quality assessment was performed using the QUALSYST appraisal tool.
UNASSIGNED: Thirty-five studies met the inclusion criteria, including a total of eight unique PRO instruments. The main findings indicated that physical function was the most concerning PRO for patients with both neobladder (NB) and ileal conduit (IC) in the short and long term. Additionally, bowel, urinary and sexual bother were concerning symptoms for patients with NB in the long-term, but only in the short-term for those with IC.
UNASSIGNED: The main issues are adequately addressed using the combination of EORTC QLQ-C30 and QLQ-BLM30 instruments.
摘要：
■为了确定根治性膀胱切除术（RC）和尿流改道（UD）后最影响患者的功能领域和症状量表，如果一个单一的仪器（或组合）充分捕获这些麻烦的症状。目前尚不清楚当前患者报告的结果（PRO）工具是否已用于评估RC和UD后患者的生活质量，足以涵盖影响患者的最麻烦的症状。
■对MEDLINE的系统搜索，EMBASE,PubMed,Cinahl和Cochrane于2000年1月至2023年5月对自2000年以来因肌肉浸润性膀胱癌而患有RC和UD的患者的原始文章进行了研究。遵循系统审查和荟萃分析（PRISMA）过程的首选报告项目。提取的数据包括使用的PRO措施，术后前12个月(短期)和12个月(长期)的领域报告和评分。功能域的保守阈值<70，症状域的保守阈值>30，用于确定每个研究中哪些PRO域可能与患者有关。使用QUALSYST评估工具进行质量评估。
■35项研究符合纳入标准，包括总共八个独特的PRO仪器。主要发现表明，在短期和长期中，新膀胱（NB）和回肠导管（IC）患者的身体功能是最关心的PRO。此外,肠,泌尿和性困扰是NB患者长期的症状，但只有在短期的IC。
■使用EORTCQLQ-C30和QLQ-BLM30仪器的组合充分解决了主要问题。
■对MEDLINE的系统搜索，EMBASE,PubMed,Cinahl和Cochrane于2000年1月至2023年5月对自2000年以来因肌肉浸润性膀胱癌而患有RC和UD的患者的原始文章进行了研究。遵循系统审查和荟萃分析（PRISMA）过程的首选报告项目。提取的数据包括使用的PRO措施，术后前12个月(短期)和12个月(长期)的领域报告和评分。功能域的保守阈值<70，症状域的保守阈值>30，用于确定每个研究中哪些PRO域可能与患者有关。使用QUALSYST评估工具进行质量评估。
■35项研究符合纳入标准，包括总共八个独特的PRO仪器。主要发现表明，在短期和长期中，新膀胱（NB）和回肠导管（IC）患者的身体功能是最关心的PRO。此外,肠,泌尿和性困扰是NB患者长期的症状，但只有在短期的IC。
■使用EORTCQLQ-C30和QLQ-BLM30仪器的组合充分解决了主要问题。
