PDF(Pubmed)
Abstract：
UNASSIGNED: It is important to figure out the immunity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) reinfection to understand the response of humans to viruses. A serological survey for previously infected populations in Jiangsu Province was conducted to compare the antibody level of SARS-CoV-2 in reinfection by Omicron or not.
UNASSIGNED: Reinfection with SARS-CoV-2 was defined as an individual being infected again after 90 days of the initial infection. Telephone surveys and face-to-face interviews were implemented to collect information. Experimental and control serum samples were collected from age-sex-matched reinfected and non-reinfected cases, respectively. IgG anti-S and neutralizing antibodies (Nab) concentrations were detected by the Magnetism Particulate Immunochemistry Luminescence Method (MCLIA). Antibody titers were log(2)-transformed and analyzed by a two-tailed Mann-Whitney U test. Subgroup analysis was conducted to explore the relationship between the strain type of primary infection, SARS-Cov-2 vaccination status, and antibody levels. Multivariate linear regression models were used to identify associations between reinfection with IgG and Nab levels.
UNASSIGNED: Six hundred thirty-one individuals were enrolled in this study, including 327 reinfected cases and 304 non-reinfected cases. The reinfection group had higher IgG (5.65 AU/mL vs. 5.22 AU/mL) and Nab (8.02 AU/mL vs. 7.25 AU/mL) levels compared to the non-reinfection group (p < 0.001). Particularly, individuals who had received SARS-CoV-2 vaccination or were initially infected with the Wild type and Delta variant showed a significant increase in antibody levels after reinfection. After adjusting demographic variables, vaccination status and the type of primary infection together, IgG and Nab levels in the reinfected group increased by log(2)-transformed 0.71 and 0.64 units, respectively (p < 0.001). This revealed that reinfection is an important factor that affects IgG and Nab levels in the population.
UNASSIGNED: Reinfection with Omicron in individuals previously infected with SARS-CoV-2 enhances IgG and Nab immune responses.
UNASSIGNED: Reinfection with SARS-CoV-2 was defined as an individual being infected again after 90 days of the initial infection. Telephone surveys and face-to-face interviews were implemented to collect information. Experimental and control serum samples were collected from age-sex-matched reinfected and non-reinfected cases, respectively. IgG anti-S and neutralizing antibodies (Nab) concentrations were detected by the Magnetism Particulate Immunochemistry Luminescence Method (MCLIA). Antibody titers were log(2)-transformed and analyzed by a two-tailed Mann-Whitney U test. Subgroup analysis was conducted to explore the relationship between the strain type of primary infection, SARS-Cov-2 vaccination status, and antibody levels. Multivariate linear regression models were used to identify associations between reinfection with IgG and Nab levels.
UNASSIGNED: Six hundred thirty-one individuals were enrolled in this study, including 327 reinfected cases and 304 non-reinfected cases. The reinfection group had higher IgG (5.65 AU/mL vs. 5.22 AU/mL) and Nab (8.02 AU/mL vs. 7.25 AU/mL) levels compared to the non-reinfection group (p < 0.001). Particularly, individuals who had received SARS-CoV-2 vaccination or were initially infected with the Wild type and Delta variant showed a significant increase in antibody levels after reinfection. After adjusting demographic variables, vaccination status and the type of primary infection together, IgG and Nab levels in the reinfected group increased by log(2)-transformed 0.71 and 0.64 units, respectively (p < 0.001). This revealed that reinfection is an important factor that affects IgG and Nab levels in the population.
UNASSIGNED: Reinfection with Omicron in individuals previously infected with SARS-CoV-2 enhances IgG and Nab immune responses.
摘要：
■重要的是要弄清楚严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）再感染的免疫力，以了解人类对病毒的反应。对江苏省先前感染人群进行了血清学调查，以比较Omicron是否再次感染SARS-CoV-2的抗体水平。
SARS-CoV-2再感染定义为个体在初次感染90天后再次感染。实施电话调查和面对面访谈以收集信息。从年龄性别匹配的再感染和非再感染病例中收集实验和对照血清样本，分别。通过磁性颗粒免疫化学发光法（MCLIA）检测IgG抗S和中和抗体（Nab）浓度。将抗体滴度进行log(2)转化并通过双尾Mann-WhitneyU检验进行分析。进行亚组分析以探讨原发感染的菌株类型之间的关系。SARS-Cov-2疫苗接种情况,和抗体水平。使用多元线性回归模型来确定再感染与IgG和Nab水平之间的关联。
■本研究纳入了6131人，包括327例再次感染病例和304例非再次感染病例。再感染组有较高的IgG（5.65AU/mLvs.5.22AU/mL）和Nab（8.02AU/mL与7.25AU/mL）水平与非再感染组相比（p<0.001）。特别是,接受SARS-CoV-2疫苗接种或最初感染野生型和Delta变体的个体在再次感染后显示抗体水平显著升高.调整人口变量后，疫苗接种状态和原发感染类型在一起，重新感染组的IgG和Nab水平增加了log（2）转化的0.71和0.64单位，分别(p<0.001)。这表明再感染是影响人群中IgG和Nab水平的重要因素。
■在先前感染SARS-CoV-2的个体中，用Omicron再感染可增强IgG和Nab免疫反应。
SARS-CoV-2再感染定义为个体在初次感染90天后再次感染。实施电话调查和面对面访谈以收集信息。从年龄性别匹配的再感染和非再感染病例中收集实验和对照血清样本，分别。通过磁性颗粒免疫化学发光法（MCLIA）检测IgG抗S和中和抗体（Nab）浓度。将抗体滴度进行log(2)转化并通过双尾Mann-WhitneyU检验进行分析。进行亚组分析以探讨原发感染的菌株类型之间的关系。SARS-Cov-2疫苗接种情况,和抗体水平。使用多元线性回归模型来确定再感染与IgG和Nab水平之间的关联。
■本研究纳入了6131人，包括327例再次感染病例和304例非再次感染病例。再感染组有较高的IgG（5.65AU/mLvs.5.22AU/mL）和Nab（8.02AU/mL与7.25AU/mL）水平与非再感染组相比（p<0.001）。特别是,接受SARS-CoV-2疫苗接种或最初感染野生型和Delta变体的个体在再次感染后显示抗体水平显著升高.调整人口变量后，疫苗接种状态和原发感染类型在一起，重新感染组的IgG和Nab水平增加了log（2）转化的0.71和0.64单位，分别(p<0.001)。这表明再感染是影响人群中IgG和Nab水平的重要因素。
■在先前感染SARS-CoV-2的个体中，用Omicron再感染可增强IgG和Nab免疫反应。
