UNASSIGNED: To compare the efficacy of botulinum toxin A (BoNT-A) injection, triamcinolone acetonide (TA) injection, topical combination of vitamin D/steroid (VitD/steroid) and placebo in improving nail psoriasis.
UNASSIGNED: A 24-week randomized intraindividual comparative-controlled study involved participants with at least 4 psoriatic fingernails, each with a total target nail psoriasis severity index (NAPSI) score of at least 3 points. Nails were randomly received different treatments; intralesional BoNT-A injection at baseline, intralesional TA at baseline and eighth week, daily topical VitD/steroid application for 16 weeks and placebo.
UNASSIGNED: Evaluation of 64 psoriatic fingernails showed a 40% reduction in the total target NAPSI score at 24 weeks following BoNT-A injection (P = .001). BoNT-A significantly improved nail bed lesions more than TA and topical VitD/steroid (P = .038), with no reported serious adverse effects.
UNASSIGNED: Relatively small sample size; hand hygiene during the COVID-19 pandemic may interfere NAPSI score evaluation.
UNASSIGNED: BoNT-A injection emerges as a promising and effective therapy for nail psoriasis, providing sustained efficacy lasting up to 6 months with a single injection.
■为了比较肉毒杆菌毒素A(BoNT-A)注射液的疗效,曲安奈德(TA)注射液,维生素D/类固醇(VitD/类固醇)和安慰剂的局部组合在改善指甲牛皮癣。
一项为期24周的随机个人比较对照研究,参与者至少有4个牛皮癣指甲,每个人的总目标指甲牛皮癣严重程度指数(NAPSI)评分至少3分。钉子随机接受不同的治疗;基线时病灶内注射BoNT-A,在基线和第八周的病灶内TA,每日局部VitD/类固醇应用16周和安慰剂。
■对64个牛皮癣指甲的评估显示,在注射BoNT-A后24周时,总目标NAPSI评分降低了40%(P=.001)。与TA和局部VitD/类固醇相比,BoNT-A显着改善了甲床病变(P=0.038),没有报告的严重不良反应。
■样本量相对较小;COVID-19大流行期间的手部卫生可能会干扰NAPSI评分评估。
■BoNT-A注射液是治疗指甲牛皮癣的一种有前途且有效的疗法,提供持续的疗效持续长达6个月与单次注射。