{Reference Type}: Journal Article
{Title}: Botulinum toxin injection shows promise in nail psoriasis: A comparative randomized controlled trial.
{Author}: Juntongjin P;Srisinlapakig S;Nitayavardhana S;
{Journal}: JAAD Int
{Volume}: 16
{Issue}: 0
{Year}: 2024 Sep
暂无{DOI}: 10.1016/j.jdin.2024.03.021
{Abstract}: <B>UNASSIGNED: </B>Nail psoriasis remains a challenging condition with limited satisfaction from current treatments. An increasing number of neuropeptides were reported in psoriatic tissue.<BR><B>UNASSIGNED: </B>To compare the efficacy of botulinum toxin A (BoNT-A) injection, triamcinolone acetonide (TA) injection, topical combination of vitamin D/steroid (VitD/steroid) and placebo in improving nail psoriasis.<BR><B>UNASSIGNED: </B>A 24-week randomized intraindividual comparative-controlled study involved participants with at least 4 psoriatic fingernails, each with a total target nail psoriasis severity index (NAPSI) score of at least 3 points. Nails were randomly received different treatments; intralesional BoNT-A injection at baseline, intralesional TA at baseline and eighth week, daily topical VitD/steroid application for 16 weeks and placebo.<BR><B>UNASSIGNED: </B>Evaluation of 64 psoriatic fingernails showed a 40% reduction in the total target NAPSI score at 24 weeks following BoNT-A injection (P = .001). BoNT-A significantly improved nail bed lesions more than TA and topical VitD/steroid (P = .038), with no reported serious adverse effects.<BR><B>UNASSIGNED: </B>Relatively small sample size; hand hygiene during the COVID-19 pandemic may interfere NAPSI score evaluation.<BR><B>UNASSIGNED: </B>BoNT-A injection emerges as a promising and effective therapy for nail psoriasis, providing sustained efficacy lasting up to 6 months with a single injection.