PDF(Pubmed)
Abstract：
UNASSIGNED: Diabetes is a major health concern globally and in Ethiopia. Ensuring optimal diabetes management through minimizing drug therapy problems is important for improving patient outcomes. However, data on the prevalence and factors associated with unmet drug-related needs in patients with diabetes in Ethiopia is limited. This systematic review and meta-analysis aims to provide a comprehensive analysis of the prevalence of unmet drug-related needs among patients with diabetes mellitus in Ethiopia.
UNASSIGNED: A thorough exploration of databases, including PubMed, Scopus, Hinari, and Embase and Google Scholar, was conducted to identify pertinent studies. Inclusion criteria involved observational studies that reported the prevalence of unmet drug-related needs in Ethiopian patients with diabetes. The quality of the studies was assessed using Joanna Briggs Institute (JBI) checklists. A random-effects meta-analysis was employed to amalgamate data on study characteristics and prevalence estimates, followed by subsequent subgroup and sensitivity analyses. Graphical and statistical assessments were employed to evaluate publication bias.
UNASSIGNED: Analysis of twelve studies involving 4,017 patients revealed a pooled prevalence of unmet drug-related needs at 74% (95% CI 63-83%). On average, each patient had 1.45 unmet drug-related needs. The most prevalent type of unmet need was ineffective drug therapy, 35% (95% CI 20-50). Type 2 diabetes, retrospective study designs, and studies from the Harari Region were associated with a higher prevalence. Frequently reported factors associated with the unmet drug-related needs includes multiple comorbidities, older age, and polypharmacy. Notably, the results indicated significant heterogeneity (I2 = 99.0%; p value < 0.001), and Egger\'s regression test revealed publication bias with p<0.001.
UNASSIGNED: The prevalence of unmet drug-related needs among diabetes patients with diabetes in Ethiopia is high with the most prevalent issue being ineffective drug therapy. Targeted interventions are needed; especially patients on multiple medications, advanced age, with comorbidities, and prolonged illness duration to improve diabetes management and outcomes.
UNASSIGNED: https://www.crd.york.ac.uk/prospero, identifier CRD42024501096.
UNASSIGNED: A thorough exploration of databases, including PubMed, Scopus, Hinari, and Embase and Google Scholar, was conducted to identify pertinent studies. Inclusion criteria involved observational studies that reported the prevalence of unmet drug-related needs in Ethiopian patients with diabetes. The quality of the studies was assessed using Joanna Briggs Institute (JBI) checklists. A random-effects meta-analysis was employed to amalgamate data on study characteristics and prevalence estimates, followed by subsequent subgroup and sensitivity analyses. Graphical and statistical assessments were employed to evaluate publication bias.
UNASSIGNED: Analysis of twelve studies involving 4,017 patients revealed a pooled prevalence of unmet drug-related needs at 74% (95% CI 63-83%). On average, each patient had 1.45 unmet drug-related needs. The most prevalent type of unmet need was ineffective drug therapy, 35% (95% CI 20-50). Type 2 diabetes, retrospective study designs, and studies from the Harari Region were associated with a higher prevalence. Frequently reported factors associated with the unmet drug-related needs includes multiple comorbidities, older age, and polypharmacy. Notably, the results indicated significant heterogeneity (I2 = 99.0%; p value < 0.001), and Egger\'s regression test revealed publication bias with p<0.001.
UNASSIGNED: The prevalence of unmet drug-related needs among diabetes patients with diabetes in Ethiopia is high with the most prevalent issue being ineffective drug therapy. Targeted interventions are needed; especially patients on multiple medications, advanced age, with comorbidities, and prolonged illness duration to improve diabetes management and outcomes.
UNASSIGNED: https://www.crd.york.ac.uk/prospero, identifier CRD42024501096.
摘要：
糖尿病是全球和埃塞俄比亚的主要健康问题。通过最小化药物治疗问题来确保最佳的糖尿病管理对于改善患者预后很重要。然而,关于埃塞俄比亚糖尿病患者未满足药物相关需求的患病率和相关因素的数据有限.本系统综述和荟萃分析旨在对埃塞俄比亚糖尿病患者中未满足的药物相关需求的患病率进行全面分析。
■彻底探索数据库，包括PubMed,Scopus,Hinari,Embase和谷歌学者，进行了相关研究。纳入标准涉及观察性研究，这些研究报告了埃塞俄比亚糖尿病患者未满足的药物相关需求的患病率。使用JoannaBriggs研究所（JBI）检查表评估研究质量。随机效应荟萃分析用于合并研究特征和患病率估计的数据，随后进行亚组和敏感性分析。采用图形和统计评估来评估发表偏倚。
■对涉及4,017名患者的12项研究的分析显示，未满足的药物相关需求的汇总患病率为74％（95％CI63-83％）。平均而言,每位患者有1.45项药物相关需求未得到满足.最普遍的未满足需求类型是无效的药物治疗，35%（95%CI20-50）。2型糖尿病,回顾性研究设计，Harari地区的研究与较高的患病率相关。经常报告的与未满足的药物相关需求相关的因素包括多种合并症，年龄较大,和多药房。值得注意的是,结果表明显著的异质性(I2=99.0%；p值<0.001)，Egger回归检验显示发表偏倚，p<0.001。
埃塞俄比亚糖尿病患者中药物相关需求未得到满足的患病率很高，最普遍的问题是药物治疗无效。需要有针对性的干预措施；特别是接受多种药物治疗的患者，高龄,有合并症，延长病程以改善糖尿病管理和预后。
■https://www.crd.约克。AC.英国/普劳里,标识符CRD42024501096。
■彻底探索数据库，包括PubMed,Scopus,Hinari,Embase和谷歌学者，进行了相关研究。纳入标准涉及观察性研究，这些研究报告了埃塞俄比亚糖尿病患者未满足的药物相关需求的患病率。使用JoannaBriggs研究所（JBI）检查表评估研究质量。随机效应荟萃分析用于合并研究特征和患病率估计的数据，随后进行亚组和敏感性分析。采用图形和统计评估来评估发表偏倚。
■对涉及4,017名患者的12项研究的分析显示，未满足的药物相关需求的汇总患病率为74％（95％CI63-83％）。平均而言,每位患者有1.45项药物相关需求未得到满足.最普遍的未满足需求类型是无效的药物治疗，35%（95%CI20-50）。2型糖尿病,回顾性研究设计，Harari地区的研究与较高的患病率相关。经常报告的与未满足的药物相关需求相关的因素包括多种合并症，年龄较大,和多药房。值得注意的是,结果表明显著的异质性(I2=99.0%；p值<0.001)，Egger回归检验显示发表偏倚，p<0.001。
埃塞俄比亚糖尿病患者中药物相关需求未得到满足的患病率很高，最普遍的问题是药物治疗无效。需要有针对性的干预措施；特别是接受多种药物治疗的患者，高龄,有合并症，延长病程以改善糖尿病管理和预后。
■https://www.crd.约克。AC.英国/普劳里,标识符CRD42024501096。
