阿曲烯醇内酯 I 通过抑制 NLRP3 炎性体激活减轻吲哚美辛诱导的大鼠胃溃疡。
关键词: NLRP3 inflammasome atractylenolide I gastric ulcer indomethacin nuclear factor-κB
Mesh : Animals NLR Family, Pyrin Domain-Containing 3 Protein / metabolism genetics Indomethacin / adverse effects Stomach Ulcer / drug therapy chemically induced metabolism Rats Sesquiterpenes / pharmacology chemistry Lactones / pharmacology chemistry Inflammasomes / metabolism genetics drug effects Male Rats, Sprague-Dawley Atractylodes / chemistry Gastric Mucosa / drug effects metabolism Humans NF-kappa B / genetics metabolism immunology Tumor Necrosis Factor-alpha / genetics metabolism immunology Interleukin-1beta / genetics metabolism immunology Caspase 1 / genetics metabolism Interleukin-6 / genetics metabolism immunology Interleukin-18 / genetics metabolism
来 源: DOI:10.1021/acs.jafc.3c08188