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Abstract：
We delineated the associations among long-term blood pressure variability (BPV), brain structure, and cognitive function.
We included 1254 adult participants from the Kailuan study. BPV was calculated from 2006 to 2020. Brain magnetic resonance imaging (MRI) and Montreal Cognitive Assessment (MoCA) were conducted in 2020.
Higher systolic BPV (SBPV) and diastolic BPV (DBPV) were associated with lower total and frontal gray matter (GM) volume, and higher SBPV was associated with lower temporal GM volume. Elevated DBPV was associated with lower volume of total brain and parietal GM, and higher white matter hyperintensity (WMH) volume. Higher SBPV and DBPV were associated with lower MoCA scores. Decreased total and regional GM volume and increased WMH volume were associated with lower MoCA scores. The association between SBPV and cognitive function was mediated by total, frontal, and temporal GM volume.
GM volume may play key roles in the association between SBPV and cognitive function.
SBPV and DBPV were negatively associated with total and regional brain volume. SBPV and DBPV were negatively associated with cognitive function. Decreased brain volume was associated with cognitive decline. GM volume mediated the negative association between SBPV and cognitive function.
We included 1254 adult participants from the Kailuan study. BPV was calculated from 2006 to 2020. Brain magnetic resonance imaging (MRI) and Montreal Cognitive Assessment (MoCA) were conducted in 2020.
Higher systolic BPV (SBPV) and diastolic BPV (DBPV) were associated with lower total and frontal gray matter (GM) volume, and higher SBPV was associated with lower temporal GM volume. Elevated DBPV was associated with lower volume of total brain and parietal GM, and higher white matter hyperintensity (WMH) volume. Higher SBPV and DBPV were associated with lower MoCA scores. Decreased total and regional GM volume and increased WMH volume were associated with lower MoCA scores. The association between SBPV and cognitive function was mediated by total, frontal, and temporal GM volume.
GM volume may play key roles in the association between SBPV and cognitive function.
SBPV and DBPV were negatively associated with total and regional brain volume. SBPV and DBPV were negatively associated with cognitive function. Decreased brain volume was associated with cognitive decline. GM volume mediated the negative association between SBPV and cognitive function.
摘要：
背景：我们描述了长期血压变异性(BPV)、大脑结构,和认知功能。
方法：我们纳入了开联研究的1254名成年参与者。BPV是从2006年到2020年计算的。2020年进行了脑磁共振成像（MRI）和蒙特利尔认知评估（MoCA）。
结果：较高的收缩期BPV（SBPV）和舒张期BPV（DBPV）与较低的总和额叶灰质（GM）体积有关，较高的SBPV与较低的时间GM体积相关。DBPV升高与总脑容量和顶叶GM减少有关，和较高的白质高强度（WMH）体积。较高的SBPV和DBPV与较低的MoCA评分相关。总GM量和区域GM量的减少以及WMH量的增加与MoCA得分的降低有关。SBPV与认知功能之间的关联是由总，额叶,和时间GM量。
结论：GM体积可能在SBPV与认知功能之间的关联中起关键作用。
结论：SBPV和DBPV与总脑容量和局部脑容量呈负相关。SBPV和DBPV与认知功能呈负相关。脑容量减少与认知能力下降有关。GM容量介导了SBPV与认知功能之间的负相关。
方法：我们纳入了开联研究的1254名成年参与者。BPV是从2006年到2020年计算的。2020年进行了脑磁共振成像（MRI）和蒙特利尔认知评估（MoCA）。
结果：较高的收缩期BPV（SBPV）和舒张期BPV（DBPV）与较低的总和额叶灰质（GM）体积有关，较高的SBPV与较低的时间GM体积相关。DBPV升高与总脑容量和顶叶GM减少有关，和较高的白质高强度（WMH）体积。较高的SBPV和DBPV与较低的MoCA评分相关。总GM量和区域GM量的减少以及WMH量的增加与MoCA得分的降低有关。SBPV与认知功能之间的关联是由总，额叶,和时间GM量。
结论：GM体积可能在SBPV与认知功能之间的关联中起关键作用。
结论：SBPV和DBPV与总脑容量和局部脑容量呈负相关。SBPV和DBPV与认知功能呈负相关。脑容量减少与认知能力下降有关。GM容量介导了SBPV与认知功能之间的负相关。
