Abstract：
Background and aim: Prescription patterns of antidepressants have changed over the years with a shift towards newer antidepressants with better tolerability and safety. Polypharmacy is common in psychiatry settings. The study aimed to evaluate the antidepressant drug prescription pattern and polypharmacy in a psychiatry outpatient setting. Investigations: This prospective observational study was conducted in a psychiatric outpatient clinic. The medication use data of eligible patients were collected. In addition, the rationale of antidepressant medication prescription, the defined daily dosage (DDD), the prescribed daily dose (PDD), and the PDD to DDD ratio were assessed. The assessment of prescription polypharmacy was conducted utilizing the framework provided by the National Association of State Mental Health Program Directors. Results: Data from 131 patients was analyzed. Major depressive disorder (32.8%) was the most common disorder for which antidepressants were prescribed. The majority, 91 (69.4%), received monotherapy. Selective serotonin reuptake inhibitors were the most frequently prescribed drugs in 69 (52.7%). Mirtazapine was the most frequently 32(24.4%) prescribed drug. Escitalopram and mirtazapine were the most commonly prescribed combination therapy (4.6%). Antipsychotic medications (37.4%) were the most widely co-prescribed medications, along with antidepressants. The PDD to DDD ratio was less than 1 for mirtazapine and imipramine; they were ≥1 for others. Psychiatric polypharmacy was documented in 87.1% of prescriptions. The total polypharmacy was not significantly (p>0.05) associated with demographic, illness, and treatment-related variables. Conclusion: Selective serotonin reuptake inhibitors were the most commonly prescribed antidepressants, monotherapy, and combination therapy. A substantial amount of patients received concomitant administration of antidepressants or psychotropic drugs, warranting careful monitoring.
摘要：
背景和目的：抗抑郁药的处方模式多年来发生了变化，转向具有更好耐受性和安全性的新型抗抑郁药。多药在精神病学环境中很常见。该研究旨在评估精神科门诊环境中抗抑郁药的处方模式和多重用药。调查：这项前瞻性观察性研究是在精神科门诊进行的。收集符合条件的患者用药数据。此外,抗抑郁药物处方的基本原理，定义的每日剂量(DDD)，规定的每日剂量（PDD），并评估了PDD与DDD的比率。处方复方药物的评估是利用国家心理健康计划主任协会提供的框架进行的。结果：分析了131例患者的数据。重度抑郁症（32.8％）是最常见的抗抑郁药处方。大多数,91（69.4%），接受单一疗法。选择性5-羟色胺再摄取抑制剂是69（52.7％）中最常用的处方药。米氮平是最常见的32种（24.4％）处方药。艾司西酞普兰和米氮平是最常用的联合治疗(4.6%)。抗精神病药物（37.4％）是最广泛的共同处方药物，还有抗抑郁药.米氮平和丙咪嗪的PDD与DDD之比小于1；其他人则≥1。在87.1％的处方中记录了精神病学多重用药。总的多重用药与人口统计学无关(p>0.05)，疾病,和治疗相关变量。结论：选择性5-羟色胺再摄取抑制剂是最常用的抗抑郁药，单一疗法,和联合治疗。大量患者同时服用抗抑郁药或精神药物，保证仔细监测。
