PDF(Pubmed)
Abstract：
BACKGROUND: Defining lipid goals solely on low-density lipoprotein-cholesterol (LDL-C) levels in Indian population may cause misclassification due to high prevalence of hypertriglyceridemia and small dense LDL-C particles. International guidelines now recommend Apoliporotein-B (Apo-B) and non-high-density lipoprotein-cholesterol (non-HDL-C) levels as alternative targets. In this study, we used a cross-sectional representative population database to determine Apo-B and non-HDL-C cut-offs corresponding to identified LDL-C targets and compared them to international guidelines.
METHODS: A community-based survey carried out in urban Delhi and adjacent rural Ballabhgarh provided lipid values for 3047 individuals. The Spearman correlation coefficient was used to evaluate the degree of relationship between Apo-B and LDL-C and non-HDL-C. Cut-off values for Apo-B and non-HDL-C were established using receiver operator curve analysis correlating with guideline-recommended LDL-C targets.
RESULTS: Spearman\'s rank correlations between Apo-B and LDL-C (0.82) and non-HDL-C and LDL-C (0.93) were significant (p < 0.05). Proposed corresponding cut-off values for LDL-C of 55, 70,100,130 and 160 mg/dl for Apo-B and non-HDL-C in our population were 75.3, 75.5, 91.3, 107.6, 119.4 mg/dL and 92.5,96.5, 123.5, 154.5, 179.5 mg/dL respectively. However, in those with triglycerides >150 mg/dl the corresponding Apo-B and non-HDL-C values were 85.1, 92.7, 103.5, 117.5 and 135 mg/dL and 124.5, 126.5, 147.5, 167.5 and 190.5 mg/L respectively.
CONCLUSIONS: Based on this study we provide Apo-B and non-HDL cut-offs corresponding to target LDL-C values in Indian patients with and without high triglycerides. It is noted that in individuals with triglycerides ≥ 150 mg/dl, the Apo-B levels are much higher than the values recommended by guidelines.
METHODS: A community-based survey carried out in urban Delhi and adjacent rural Ballabhgarh provided lipid values for 3047 individuals. The Spearman correlation coefficient was used to evaluate the degree of relationship between Apo-B and LDL-C and non-HDL-C. Cut-off values for Apo-B and non-HDL-C were established using receiver operator curve analysis correlating with guideline-recommended LDL-C targets.
RESULTS: Spearman\'s rank correlations between Apo-B and LDL-C (0.82) and non-HDL-C and LDL-C (0.93) were significant (p < 0.05). Proposed corresponding cut-off values for LDL-C of 55, 70,100,130 and 160 mg/dl for Apo-B and non-HDL-C in our population were 75.3, 75.5, 91.3, 107.6, 119.4 mg/dL and 92.5,96.5, 123.5, 154.5, 179.5 mg/dL respectively. However, in those with triglycerides >150 mg/dl the corresponding Apo-B and non-HDL-C values were 85.1, 92.7, 103.5, 117.5 and 135 mg/dL and 124.5, 126.5, 147.5, 167.5 and 190.5 mg/L respectively.
CONCLUSIONS: Based on this study we provide Apo-B and non-HDL cut-offs corresponding to target LDL-C values in Indian patients with and without high triglycerides. It is noted that in individuals with triglycerides ≥ 150 mg/dl, the Apo-B levels are much higher than the values recommended by guidelines.
摘要：
背景：在印度人群中，仅根据低密度脂蛋白-胆固醇（LDL-C）水平定义脂质目标可能会由于高甘油三酯血症和低密度LDL-C颗粒的高患病率而导致分类错误。国际指南现在推荐载脂蛋白B（Apo-B）和非高密度脂蛋白胆固醇（非HDL-C）水平作为替代目标。在这项研究中,我们使用横断面代表性人群数据库来确定与已确定的LDL-C目标相对应的Apo-B和非HDL-C截止值,并将它们与国际指南进行比较.
方法：在德里市区和邻近的农村Ballabhgarh进行的一项基于社区的调查提供了3047人的血脂值。Spearman相关系数用于评估Apo-B与LDL-C和非HDL-C之间的关系程度。使用与指南推荐的LDL-C目标相关的受试者操作曲线分析来建立Apo-B和非HDL-C的截止值。
结果：Apo-B和LDL-C（0.82）与非HDL-C和LDL-C（0.93）之间的Spearman等级相关性显着（p<0.05）。在我们的人群中，Apo-B和非HDL-C的LDL-C分别为55、70、100、130和160mg/dl，分别为75.3、75.5、91.3、107.6、119.4mg/dL和92.5、96.5、123.5、154.5、179.5mg/dL。然而,在甘油三酯>150mg/dl的患者中，相应的Apo-B和非HDL-C值分别为85.1、92.7、103.5、117.5和135mg/dL和124.5、126.5、147.5、167.5和190.5mg/L。
结论：基于这项研究，我们提供了与有或没有高甘油三酯的印度患者的目标LDL-C值相对应的Apo-B和非HDL截止值。值得注意的是，在甘油三酯>=150mg/dl的个体中，Apo-B水平远高于指南建议的值。
方法：在德里市区和邻近的农村Ballabhgarh进行的一项基于社区的调查提供了3047人的血脂值。Spearman相关系数用于评估Apo-B与LDL-C和非HDL-C之间的关系程度。使用与指南推荐的LDL-C目标相关的受试者操作曲线分析来建立Apo-B和非HDL-C的截止值。
结果：Apo-B和LDL-C（0.82）与非HDL-C和LDL-C（0.93）之间的Spearman等级相关性显着（p<0.05）。在我们的人群中，Apo-B和非HDL-C的LDL-C分别为55、70、100、130和160mg/dl，分别为75.3、75.5、91.3、107.6、119.4mg/dL和92.5、96.5、123.5、154.5、179.5mg/dL。然而,在甘油三酯>150mg/dl的患者中，相应的Apo-B和非HDL-C值分别为85.1、92.7、103.5、117.5和135mg/dL和124.5、126.5、147.5、167.5和190.5mg/L。
结论：基于这项研究，我们提供了与有或没有高甘油三酯的印度患者的目标LDL-C值相对应的Apo-B和非HDL截止值。值得注意的是，在甘油三酯>=150mg/dl的个体中，Apo-B水平远高于指南建议的值。
