BACKGROUND: The optimal mobilization and harvesting of peripheral blood stem cells is critical to the success of the stem cell transplant. The ideal strategy that promotes better cell yields, with sustainable use of resources and assuring patient safety, should be pursued.
METHODS: PBSC collections for autologous stem cell transplant data according to a fixed-processed volume strategy (One Size Fits All) or individualized to patients CD34+ peripheral blood content and target approach (Custom-Tailored or CT) were retrospectively compared.
RESULTS: A total of 263 collections from 142 patients were assessed. The majority of patients were male, had multiple myeloma and were mobilized with isolated G-CSF. The CT strategy promoted a significantly higher CD34+ cell yield when the pre-collection CD34 was lower than 20/µl (1.02 ± 0.16 versus 1.36 ± 0.23, p < 0.001) and also a decrease in the proportion of mobilization cycles that needed 3 apheresis (31% versus 14%, p = 0.02). There was no difference in apheresis-related adverse events between the groups.
CONCLUSIONS: Tailoring the apheresis procedures to the patient-specific characteristics and objectives, can effectively promote better patient outcome.
背景:外周血干细胞的最佳动员和收获对于干细胞移植的成功至关重要。促进更好的细胞产量的理想策略,可持续利用资源并确保患者安全,应该追求。
方法:根据固定处理体积策略(OneSizeFitsAll)或针对患者个体化CD34+外周血含量和目标方法(定制或CT)收集的PBSC自体干细胞移植数据进行回顾性比较。
结果:共评估了来自142例患者的263个样本。大多数患者是男性,患有多发性骨髓瘤,并用分离的G-CSF动员。当收集前的CD34低于20/μl(1.02±0.16对1.36±0.23,p<0.001)时,CT策略促进了CD34细胞产量的显着提高,并且需要3次单采术的动员周期比例也降低了(31%对14%,p=0.02)。两组之间的单采相关不良事件没有差异。
结论:根据患者的特定特征和目标定制单采程序,能有效促进更好的患者预后。