METHODS: The functional MRI data from 82 PD and 97 controls were included. Intrinsic FC between each pair of 160 regions, 6 intra-networks, and 15 inter-networks were analyzed. The topological properties were explored.
RESULTS: PD patients showed altered FCs within the right insula, between frontal cortex-posterior cingulate cortex (PCC), frontal cortex-cerebellum, and PCC-occipital cortex (corrected P values < 0.001). Lower connections within the Sensorimotor Network (SMN) and SMN-Occipital Network (OCN) were detected (P values < 0.05). Various decreased global and local network features were found in PD (P values < 0.05). In addition, significant correlations were found between PD symptoms and nodal efficiency (Ne) in the insula (r = -0.273, P = 0.016), and the FC of the intra-insula (r = -0.226, P = 0.041).
CONCLUSIONS: PD patients present with abnormal functional brain networks, especially the decreased FC and Ne within insula, suggesting that dysfunction of information integration plays an important role in PD.
方法:纳入82个PD和97个对照的功能MRI数据。每对160个区域之间的本征FC,6个内部网络,并对15个网络间进行了分析。探索了拓扑性质。
结果:PD患者显示右侧脑岛内的FCs改变,额叶皮质-后扣带皮质(PCC)之间,额叶皮质-小脑,和PCC-枕骨皮质(校正后的P值<0.001)。在感觉运动网络(SMN)和SMN-枕骨网络(OCN)内检测到较低的连接(P值<0.05)。在PD中发现了各种减少的全局和局部网络特征(P值<0.05)。此外,脑岛的PD症状与结节效率(Ne)之间存在显着相关性(r=-0.273,P=0.016),和岛内FC(r=-0.226,P=0.041)。
结论:PD患者存在功能异常的脑网络,特别是脑岛内的FC和Ne减少,提示信息整合功能障碍在PD中起重要作用。