PDF(Pubmed)
Abstract：
OBJECTIVE: The genotype distribution of human papillomavirus (HPV) infection varies greatly in different regions. This study aims to determine the prevalence and type-specific distribution of HPV among females from Chengdu and Aba in Sichuan Province, which differ in geographical location, economic status, and living habits. These can serve as evidence of epidemic patterns for future design and implementation of vaccination and screening programs.
METHODS: A retrospective cross-sectional study was conducted on 144 113 women who underwent cervical screening at Chengdu Women\'s and Children\'s Central Hospital from January 2015 to September 2020. Meanwhile, 1799 samples from February 2018 to December 2021 were collected from Aba Maternal and Child Health Hospital. HPV DNA genotype testing was performed using real-time PCR. The overall prevalence, annual trend, age-specific prevalence, and type distribution were analyzed.
RESULTS: The overall HPV prevalence was 22.51% in Chengdu. During 2015-2020, the highest prevalence rate was observed in 2018. Age-specific HPV distribution displayed a bimodal distribution among women aged ≤25 or ≥46 years old. The top three prevalent genotypes were HPV52, -16, and -58. Although the total prevalence of HPV in Aba was 14.23%, there was an upward trend from 2018 to 2021. However, no significant differences were identified in HPV infection rate across all age groups. HPV52, -53, and -16 were the major genotypes. Furthermore, single-type HPV infections and high-risk HPV infections were identified as the most common infection types in both regions.
CONCLUSIONS: Our findings demonstrate the overall prevalence of HPV was still high in Chengdu and Aba. The age-specific prevalence distribution demonstrated different patterns. Non-vaccine-covered HR-HPV53, -51and LR-HPV81, -CP8304 were frequently detected, which was worth significant clinical attention. In summary, regional HPV screening provides valuable clinical guidance for cervical cancer prevention and vaccine selection in Western China.
METHODS: A retrospective cross-sectional study was conducted on 144 113 women who underwent cervical screening at Chengdu Women\'s and Children\'s Central Hospital from January 2015 to September 2020. Meanwhile, 1799 samples from February 2018 to December 2021 were collected from Aba Maternal and Child Health Hospital. HPV DNA genotype testing was performed using real-time PCR. The overall prevalence, annual trend, age-specific prevalence, and type distribution were analyzed.
RESULTS: The overall HPV prevalence was 22.51% in Chengdu. During 2015-2020, the highest prevalence rate was observed in 2018. Age-specific HPV distribution displayed a bimodal distribution among women aged ≤25 or ≥46 years old. The top three prevalent genotypes were HPV52, -16, and -58. Although the total prevalence of HPV in Aba was 14.23%, there was an upward trend from 2018 to 2021. However, no significant differences were identified in HPV infection rate across all age groups. HPV52, -53, and -16 were the major genotypes. Furthermore, single-type HPV infections and high-risk HPV infections were identified as the most common infection types in both regions.
CONCLUSIONS: Our findings demonstrate the overall prevalence of HPV was still high in Chengdu and Aba. The age-specific prevalence distribution demonstrated different patterns. Non-vaccine-covered HR-HPV53, -51and LR-HPV81, -CP8304 were frequently detected, which was worth significant clinical attention. In summary, regional HPV screening provides valuable clinical guidance for cervical cancer prevention and vaccine selection in Western China.
摘要：
目的：不同地区人乳头瘤病毒(HPV)感染基因型分布差异较大。本研究旨在确定四川成都和阿坝地区女性HPV的患病率和类型特异性分布。地理位置不同，经济地位,和生活习惯。这些可以作为未来设计和实施疫苗接种和筛查计划的流行模式的证据。
方法：对2015年1月至2020年9月在成都市妇女儿童中心医院行宫颈筛查的144113例妇女进行回顾性横断面研究。同时,从2018年2月至2021年12月，从阿坝妇幼保健院收集了1799个样本。使用实时PCR进行HPVDNA基因型测试。总体患病率，年度趋势,特定年龄的患病率，并对类型分布进行了分析。
结果：成都HPV总体患病率为22.51%。在2015-2020年期间，2018年的患病率最高。年龄特异性HPV分布在≤25岁或≥46岁的女性中呈双峰分布。前三个流行基因型是HPV52、-16和-58。尽管Aba中HPV的总患病率为14.23％，从2018年到2021年有上升趋势。然而,所有年龄组的HPV感染率无显著差异.HPV52、-53和-16是主要的基因型。此外，单一型HPV感染和高危型HPV感染被确定为两个地区最常见的感染类型.
结论：我们的研究结果表明，成都和阿坝州的HPV总体患病率仍然很高。特定年龄的患病率分布表现出不同的模式。经常检测到非疫苗覆盖的HR-HPV53，-51和LR-HPV81，-CP8304，值得临床重视。总之,区域HPV筛查为中国西部地区宫颈癌预防和疫苗选择提供了有价值的临床指导.
方法：对2015年1月至2020年9月在成都市妇女儿童中心医院行宫颈筛查的144113例妇女进行回顾性横断面研究。同时,从2018年2月至2021年12月，从阿坝妇幼保健院收集了1799个样本。使用实时PCR进行HPVDNA基因型测试。总体患病率，年度趋势,特定年龄的患病率，并对类型分布进行了分析。
结果：成都HPV总体患病率为22.51%。在2015-2020年期间，2018年的患病率最高。年龄特异性HPV分布在≤25岁或≥46岁的女性中呈双峰分布。前三个流行基因型是HPV52、-16和-58。尽管Aba中HPV的总患病率为14.23％，从2018年到2021年有上升趋势。然而,所有年龄组的HPV感染率无显著差异.HPV52、-53和-16是主要的基因型。此外，单一型HPV感染和高危型HPV感染被确定为两个地区最常见的感染类型.
结论：我们的研究结果表明，成都和阿坝州的HPV总体患病率仍然很高。特定年龄的患病率分布表现出不同的模式。经常检测到非疫苗覆盖的HR-HPV53，-51和LR-HPV81，-CP8304，值得临床重视。总之,区域HPV筛查为中国西部地区宫颈癌预防和疫苗选择提供了有价值的临床指导.
