PDF(Pubmed)
Abstract：
Monosodium glutamate (MSG) is the sodium compound derived from glutamic acid. Excessive daily ingestion of MSG leads to elevated amounts of glutamic acid in the bloodstream, which can be detrimental to brain structures. Camellia sinensis, often known as green tea (GT), is a rich source of essential hexogen antioxidants that are necessary for the body. Thirty-two adult male albino rats were divided into four groups (n = 8). Group 1 served as a control -ve group. Group 2 was given GT (1.5 ml/rat/day). Group 3 was given MSG (600 mg/kg/day). Group 4 was given MSG (600 mg/kg/day) and GT (1.5 ml/rat/day). All treatments were given orally for 28 days. MSG administration resulted in significant neurotoxicity in rats that was revealed by the significant reduction of serum concentration of glutathione peroxidase (GPx) and nitric oxide (NO), and the significant elevation of total antioxidant capacity (TAC) accompanied by the significant reduction of levels of serum monoamines (dopamine, serotonin, and norepinephrine) and histological changes in the hippocampus area CA1, dentate gyrus, and cerebellar cortex and positive immunohistochemical staining of glial fibrillary acidic proteins (GFAP) and calretinin. Administration of GT with MSG counteracted the MSG-mediated oxidative stress by significantly increasing serum concentrations of GPX and NO and significantly decreasing concentrations of TAC. Furthermore, GT significantly increased levels of serum monoamines (dopamine, serotonin, and norepinephrine). Moreover, it ameliorated the histological changes, GFAP, and calretinin immunostaining in brain tissues. It is envisaged that GT will serve as a viable protective choice for the inclusion of the neurotoxicity treatment procedure.
摘要：
味精(MSG)是衍生自谷氨酸的钠化合物。每天过量摄入味精会导致血液中谷氨酸含量升高，这可能对大脑结构有害。茶树,通常被称为绿茶（GT），是人体必需的必需己方抗氧化剂的丰富来源。将32只成年雄性白化病大鼠分为四组（n=8）。第1组作为对照组。第2组给予GT(1.5ml/大鼠/天)。第3组给予MSG(600mg/kg/天)。第4组给予MSG(600mg/kg/天)和GT(1.5ml/大鼠/天)。所有治疗均口服28天。MSG给药导致大鼠明显的神经毒性，这通过谷胱甘肽过氧化物酶（GPx）和一氧化氮（NO）的血清浓度显着降低来揭示。和总抗氧化能力（TAC）的显着提高伴随着血清单胺（多巴胺，血清素,和去甲肾上腺素）和海马区CA1，齿状回的组织学变化，和小脑皮质，胶质纤维酸性蛋白（GFAP）和钙视网膜素的免疫组织化学染色阳性。用MSG施用GT通过显著增加GPX和NO的血清浓度和显著降低TAC的浓度来抵消MSG介导的氧化应激。此外，GT显着增加血清单胺（多巴胺，血清素,和去甲肾上腺素）。此外，它改善了组织学变化，GFAP,和脑组织中的钙视网膜素免疫染色。设想GT将作为包括神经毒性治疗程序的可行保护性选择。
