Abstract：
This study examined the impact of Semen raphani on the absorption of ginsenosides from Panax ginseng C.A. Meyer (ginseng) using a Caco-2 cell model and Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry (UPLC-ESI-MS). Six primary ginsenosides (Rg1, Re, Rb1, Rb2, Rc, Rd) were quantified. Results showed that Semen Raphani increased the efflux rate of ginsenosides, particularly at higher concentrations, suggesting it inhibits their absorption. The research elucidates the intestinal absorption process of ginsenosides and the antagonistic mechanism of Semen Raphani against ginseng.
摘要：
本研究使用Caco-2细胞模型和超高效液相色谱-电喷雾电离-串联质谱法（UPLC-ESI-MS），研究了raphani对人参C.A.Meyer（人参）中人参皂苷吸收的影响。六种主要人参皂苷（Rg1，Re，Rb1,Rb2,Rc,Rd)进行了量化。结果表明，莱佛尼提高了人参皂苷的外排率，特别是在较高的浓度下，表明它抑制了它们的吸收。该研究阐明了人参皂苷的肠道吸收过程以及莱佛子对人参的拮抗机制。
