Abstract：
Thyroid Eye Disease (TED) is an inflammatory autoimmune condition affecting the eyes, often associated with Graves\' disease. Inflammation is important in TED, involving immune cells and orbital tissues. While inflammatory markers have been studied in other diseases, their role in TED is unclear. We included 734 participants from 5 eligible studies investigated associations between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) and TED. Initial analysis found no significant differences in these markers between TED and control groups. However, sensitivity analysis excluding an outlier study revealed significant differences in NLR, PLR, and MLR between groups, suggesting the potential association between these inflammatory markers and TED. More research is needed, but these findings indicate complex TED pathogenesis and that inflammation may offer insights for TED diagnosis and management.
摘要：
甲状腺眼病（TED）是一种影响眼睛的炎症性自身免疫性疾病，通常与格雷夫斯病有关。炎症在TED中很重要，涉及免疫细胞和眼眶组织。虽然炎症标志物已经在其他疾病中进行了研究，他们在TED中的作用尚不清楚。我们纳入了来自5项符合条件的研究的734名参与者，这些研究调查了中性粒细胞与淋巴细胞比率（NLR）之间的关联。血小板与淋巴细胞比率（PLR），和单核细胞与淋巴细胞比率（MLR）和TED。初步分析发现TED和对照组之间的这些标记没有显着差异。然而,不包括异常研究的敏感性分析显示，NLR存在显著差异，PLR,和群体之间的MLR，提示这些炎症标志物与TED之间的潜在关联。需要更多的研究，但这些发现表明TED发病机制复杂,炎症可能为TED的诊断和治疗提供见解.
