Abstract：
Riparin A is a synthetic form of natural riparins. Acute scale studies that take into consideration the structure-activity relationship have shown preliminary evidence of antidepressant and anxiolytic effects of riparin A, similar to that already known for other riparins. However, for better pharmacological characterization of this new compound, further studies are required. The aim of this work was to evaluate the effect of chronic treatment with riparin A (10 mg/kg; intraperitoneally) on depressive-like behavior in the forced swimming test and tail suspension test, as well as the reduction of anhedonia in the sucrose preference test, and on anxiety-like behavior in the open field and elevated plus maze apparatus, triggered in rats previously subjected to unpredictable chronic mild stress by 4 weeks. In addition, a pentobarbital-induced sleep time test was also used. Riparin A reduced the duration of immobility in both the forced swimming test and tail suspension test, as well as attenuated the anhedonia in the sucrose preference test. Furthermore, riparin A appears to produce anxiolytic effects in rats exposed to an open field and elevated plus maze, while increasing the alertness/vigilance in rats submitted to pentobarbital-induced sleep time test, without altering their locomotor integrity. Our results suggest that chronic riparin A appears to be a potential pharmacological target for new studies on the control of depression- and anxiety-like behaviors in stressed rats.
摘要：
riparinA是天然riparin的合成形式。考虑到结构-活性关系的急性规模研究显示了利帕林A的抗抑郁和抗焦虑作用的初步证据，与其他riparins已知的类似。然而,为了更好地表征这种新化合物，需要进一步的研究。这项工作的目的是评估在强迫游泳试验和尾部悬吊试验中，用riparinA（10mg/kg；腹膜内）进行慢性治疗对抑郁样行为的影响，以及蔗糖偏好测试中快感缺乏症的减少，以及在开阔田野和高架迷宫装置中的焦虑样行为，在4周前受到不可预测的慢性轻度应激的大鼠中触发。此外,还使用了戊巴比妥诱导的睡眠时间测试。RiparinA在强迫游泳试验和尾部悬吊试验中都减少了不动的持续时间，以及减轻蔗糖偏好测试中的快感缺乏。此外，利帕林A似乎在暴露于开放视野和高架迷宫的大鼠中产生抗焦虑作用，在增加接受戊巴比妥诱导的睡眠时间测试的大鼠的警觉性/警惕性的同时，而不会改变他们的运动完整性。我们的结果表明，慢性riparinA似乎是控制压力大鼠抑郁和焦虑样行为的新研究的潜在药理靶标。
