PDF(Pubmed)
Abstract：
Kaposi\'s sarcoma (KS) and multicentric Castleman\'s disease (MCD) are both linked to human herpesvirus-8 (HHV-8) infection which most commonly affects people living with human immunodeficiency virus (HIV). Herein, we describe the case of a 57-year-old patient who has been admitted for fever, night sweats, weight loss, and diffuse lymphadenopathy with abdominal pain. HIV status was confirmed by a positive Western blot test. His initial CD4 cell count was equal to 270 cells/µL. A histological study of a peripheral lymph node concluded that KS is associated with MCD. These two conditions found in the same patient highlight the malignant potential of HHV-8, particularly in the case of HIV-induced immunodeficiency.
摘要：
卡波西肉瘤（KS）和多中心Castleman病（MCD）均与人类疱疹病毒8（HHV-8）感染有关，后者最常见于感染人类免疫缺陷病毒（HIV）的人。在这里，我们描述了一名57岁的病人因发烧入院的情况，盗汗,减肥,和弥漫性淋巴结肿大伴腹痛。通过阳性的Western印迹试验确认HIV状态。他的初始CD4细胞计数等于270细胞/微升。对周围淋巴结的组织学研究得出结论，KS与MCD有关。在同一患者中发现的这两种情况突出了HHV-8的恶性潜力，特别是在HIV诱导的免疫缺陷的情况下。
