{Reference Type}: Case Reports
{Title}: HHV-8 Linked to Kaposi's Sarcoma and Castleman's Disease in HIV-1-infected patient: Case Report and Review of the Literature.
{Author}: Zaghdoudi A;Harrabi H;Tiouiri Benaissa H;
{Journal}: Int J Hematol Oncol Stem Cell Res
{Volume}: 18
{Issue}: 2
{Year}: 2024 Apr 1
暂无{DOI}: 10.18502/ijhoscr.v18i2.15378
{Abstract}: Kaposi's sarcoma (KS) and multicentric Castleman's disease (MCD) are both linked to human herpesvirus-8 (HHV-8) infection which most commonly affects people living with human immunodeficiency virus (HIV).  Herein, we describe the case of a 57-year-old patient who has been admitted for fever, night sweats, weight loss, and diffuse lymphadenopathy with abdominal pain. HIV status was confirmed by a positive Western blot test. His initial CD4 cell count was equal to 270 cells/µL. A histological study of a peripheral lymph node concluded that KS is associated with MCD. These two conditions found in the same patient highlight the malignant potential of HHV-8, particularly in the case of HIV-induced immunodeficiency.