PDF(Pubmed)
Abstract：
UNASSIGNED: Some studies have examined the relationship between premenstrual syndrome (PMS) and antenatal depression. However, retrospective designs were used to obtain the PMS experiences. Different from such earlier research, this study aims to investigate the association between PMS before pregnancy and antenatal depression with a prospective design.
UNASSIGNED: This is a secondary analysis of a randomized controlled trial (RCT) conducted among pregnant women. Premenstrual symptoms before pregnancy of the participants were obtained prospectively via a period tracking app. At the baseline of the RCT, 5073 women participated. Of those, 3004 had one or more symptom records related to menstruation 1 year before pregnancy. The outcome, antenatal depression, was assessed using the Edinburgh Postnatal Depression Scale (EPDS) at the RCT baseline, and the cut-off value was set at 11. For covariates, age, education, planned pregnancy, and the number of children were also measured at the same time. Multiple logistic regression analyses were employed to estimate the odds ratio (OR) of having antenatal depression, adjusting for the covariates.
UNASSIGNED: A total of 366 individuals who had three or more cycles of menstrual-related symptom records were included in the analyses, and of those 52 were applicable to PMS before pregnancy. There was no significant association between PMS and antenatal depression (adjusted OR = 1.28, P = 0.61).
UNASSIGNED: The present study was the first study to utilize a prospective design to obtain premenstrual symptoms. Future research should consider using a validated and objective measure of PMS diagnosis and a larger sample.
UNASSIGNED: This is a secondary analysis of a randomized controlled trial (RCT) conducted among pregnant women. Premenstrual symptoms before pregnancy of the participants were obtained prospectively via a period tracking app. At the baseline of the RCT, 5073 women participated. Of those, 3004 had one or more symptom records related to menstruation 1 year before pregnancy. The outcome, antenatal depression, was assessed using the Edinburgh Postnatal Depression Scale (EPDS) at the RCT baseline, and the cut-off value was set at 11. For covariates, age, education, planned pregnancy, and the number of children were also measured at the same time. Multiple logistic regression analyses were employed to estimate the odds ratio (OR) of having antenatal depression, adjusting for the covariates.
UNASSIGNED: A total of 366 individuals who had three or more cycles of menstrual-related symptom records were included in the analyses, and of those 52 were applicable to PMS before pregnancy. There was no significant association between PMS and antenatal depression (adjusted OR = 1.28, P = 0.61).
UNASSIGNED: The present study was the first study to utilize a prospective design to obtain premenstrual symptoms. Future research should consider using a validated and objective measure of PMS diagnosis and a larger sample.
摘要：
■一些研究检查了经前综合征（PMS）与产前抑郁症之间的关系。然而,回顾性设计用于获得PMS经验.与之前的研究不同,本研究旨在通过前瞻性设计调查孕前PMS与产前抑郁之间的关系.
■这是一项在孕妇中进行的随机对照试验（RCT）的二次分析。参与者怀孕前的经前症状是通过经期跟踪应用程序前瞻性获得的。在RCT的基线，5073名妇女参加。其中,3004在怀孕前1年有一个或多个与月经有关的症状记录。结果,产前抑郁症,在RCT基线使用爱丁堡产后抑郁量表（EPDS）进行评估，截止值设定为11。对于协变量，年龄,教育,计划怀孕,同时测量了儿童的数量。采用多元逻辑回归分析来估计产前抑郁症的比值比（OR），调整协变量。
■总共366名具有三个或更多月经相关症状记录的个体被纳入分析，其中52例适用于怀孕前的PMS。PMS与产前抑郁无显著相关性(校正OR=1.28,P=0.61)。
■本研究是第一个利用前瞻性设计获得经前症状的研究。未来的研究应该考虑使用经过验证和客观的PMS诊断方法和更大的样本。
■这是一项在孕妇中进行的随机对照试验（RCT）的二次分析。参与者怀孕前的经前症状是通过经期跟踪应用程序前瞻性获得的。在RCT的基线，5073名妇女参加。其中,3004在怀孕前1年有一个或多个与月经有关的症状记录。结果,产前抑郁症,在RCT基线使用爱丁堡产后抑郁量表（EPDS）进行评估，截止值设定为11。对于协变量，年龄,教育,计划怀孕,同时测量了儿童的数量。采用多元逻辑回归分析来估计产前抑郁症的比值比（OR），调整协变量。
■总共366名具有三个或更多月经相关症状记录的个体被纳入分析，其中52例适用于怀孕前的PMS。PMS与产前抑郁无显著相关性(校正OR=1.28,P=0.61)。
■本研究是第一个利用前瞻性设计获得经前症状的研究。未来的研究应该考虑使用经过验证和客观的PMS诊断方法和更大的样本。
